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用于高效选择性抗癌药物研发的海洋来源双吲哚类化合物

Marine-Derived Bisindoles for Potent Selective Cancer Drug Discovery and Development.

作者信息

Xu Mengwei, Bai Zhaofang, Xie Baocheng, Peng Rui, Du Ziwei, Liu Yan, Zhang Guangshuai, Yan Si, Xiao Xiaohe, Qin Shuanglin

机构信息

Hubei Engineering Research Center of Traditional Chinese Medicine of South Hubei Province, School of Pharmacy, Xianning Medical College, Hubei University of Science and Technology, Xianning 437100, China.

Senior Department of Hepatology, The Fifth Medical Center of PLA General Hospital, Beijing 100039, China.

出版信息

Molecules. 2024 Feb 21;29(5):933. doi: 10.3390/molecules29050933.

DOI:10.3390/molecules29050933
PMID:38474445
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10935119/
Abstract

Marine-derived bisindoles exhibit structural diversity and exert anti-cancer influence through multiple mechanisms. Comprehensive research has shown that the development success rate of drugs derived from marine natural products is four times higher than that of other natural derivatives. Currently, there are 20 marine-derived drugs used in clinical practice, with 11 of them demonstrating anti-tumor effects. This article provides a thorough review of recent advancements in anti-tumor exploration involving 167 natural marine bisindole products and their derivatives. Not only has enzastaurin entered clinical practice, but there is also a successfully marketed marine-derived bisindole compound called midostaurin that is used for the treatment of acute myeloid leukemia. In summary, investigations into the biological activity and clinical progress of marine-derived bisindoles have revealed their remarkable selectivity, minimal toxicity, and efficacy against various cancer cells. Consequently, they exhibit immense potential in the field of anti-tumor drug development, especially in the field of anti-tumor drug resistance. In the future, these compounds may serve as promising leads in the discovery and development of novel cancer therapeutics.

摘要

海洋来源的双吲哚类化合物具有结构多样性，并通过多种机制发挥抗癌作用。综合研究表明，海洋天然产物衍生药物的开发成功率比其他天然衍生物高出四倍。目前，有20种海洋来源的药物用于临床实践，其中11种具有抗肿瘤作用。本文全面综述了167种天然海洋双吲哚类产物及其衍生物在抗肿瘤研究方面的最新进展。不仅恩杂鲁胺已进入临床实践，还有一种成功上市的海洋来源双吲哚类化合物米哚妥林，用于治疗急性髓系白血病。总之，对海洋来源双吲哚类化合物的生物活性和临床进展的研究表明，它们具有显著的选择性、低毒性以及对各种癌细胞的疗效。因此，它们在抗肿瘤药物开发领域，尤其是在抗肿瘤耐药性领域具有巨大潜力。未来，这些化合物可能成为发现和开发新型癌症治疗药物的有前景的先导物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f0c/10935119/b337023abc99/molecules-29-00933-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f0c/10935119/27b716b093df/molecules-29-00933-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f0c/10935119/f4f1ef48b21d/molecules-29-00933-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f0c/10935119/a72f292d2a69/molecules-29-00933-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f0c/10935119/442c1889aa69/molecules-29-00933-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f0c/10935119/76c4f4560be1/molecules-29-00933-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f0c/10935119/34768e201d32/molecules-29-00933-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f0c/10935119/0d56f803166e/molecules-29-00933-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f0c/10935119/52065c07f347/molecules-29-00933-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f0c/10935119/912d07e53e5b/molecules-29-00933-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f0c/10935119/b337023abc99/molecules-29-00933-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f0c/10935119/27b716b093df/molecules-29-00933-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f0c/10935119/f4f1ef48b21d/molecules-29-00933-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f0c/10935119/a72f292d2a69/molecules-29-00933-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f0c/10935119/442c1889aa69/molecules-29-00933-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f0c/10935119/76c4f4560be1/molecules-29-00933-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f0c/10935119/34768e201d32/molecules-29-00933-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f0c/10935119/0d56f803166e/molecules-29-00933-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f0c/10935119/52065c07f347/molecules-29-00933-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f0c/10935119/912d07e53e5b/molecules-29-00933-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f0c/10935119/b337023abc99/molecules-29-00933-g010.jpg

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