Quebec Heart and Lung Institute Research Center (CRIUCPQ), Quebec, QC, Canada; Faculty of Pharmacy, Laval University, Quebec, QC, Canada.
Quebec Heart and Lung Institute Research Center (CRIUCPQ), Quebec, QC, Canada; School of Nutrition, Faculty of Agricultural and Nutrition Sciences, Laval University, Quebec, QC, Canada.
Curr Opin Pharmacol. 2020 Jun;52:67-74. doi: 10.1016/j.coph.2020.06.005. Epub 2020 Jul 17.
This review addresses the impact of bariatric surgery on the endocrine aspects of white adipose tissue, muscle and the liver. We describe literature supporting the notion that adipokines, myokines and hepatokines likely act in concert and drive many of the long-term metabolic improvements following surgery. Circulating adiponectin is increased while secretion of pro-inflammatory interleukins (1, 6 and 8) decreases, alongside leptin secretion. The metabolic improvements observed in the muscle might relate to reduction of myokines contributing to insulin resistance (including myostatin, brain-derived neurotrophic factor and fibroblast growth factor-21). Subject to exception, hepatokine secretion is generally increased (such as insulin-like growth factor-binding protein 2, adropin and sex hormone-binding globulin). In conclusion, bariatric surgery restores metabolic functions by enhancing the time-dependent secretion of anti-inflammatory, insulin-sensitizing and antilipemic factors. Further research is needed to understand the molecular mechanisms by which these factors may trigger the remission of obesity-related comorbidities following bariatric surgery.
这篇综述探讨了减重手术对白色脂肪组织、肌肉和肝脏内分泌方面的影响。我们描述了支持以下观点的文献，即脂肪因子、肌因子和肝因子可能协同作用，推动手术后许多长期代谢改善。循环脂联素增加，而促炎细胞因子（1、6 和 8）的分泌减少，同时瘦素分泌也减少。在肌肉中观察到的代谢改善可能与减少导致胰岛素抵抗的肌因子有关（包括肌肉生长抑制素、脑源性神经营养因子和成纤维细胞生长因子 21）。一般来说，肝因子的分泌增加（如胰岛素样生长因子结合蛋白 2、adropin 和性激素结合球蛋白）。总之，减重手术通过增强抗炎、胰岛素增敏和抗脂因子的时间依赖性分泌来恢复代谢功能。需要进一步研究以了解这些因子可能通过何种分子机制触发减重手术后肥胖相关合并症的缓解。
