Shen Leilei, Lin Jixing, Ren Zhipeng, Wang Bailin, Liu You, Yuan Jing, Zhan Lianbin
Department of Thoracic Surgery, Hainan Branch of PLA General Hospital, Sanya, 572013, China.
Department of Pathology, Hainan Branch of PLA General Hospital, Sanya, China.
J Cardiothorac Surg. 2020 Jul 20;15(1):177. doi: 10.1186/s13019-020-01224-w.
Clear cell tumors of the lung (CCTLs) are rare and mostly benign pulmonary neoplasms arising from perivascular epithelioid cells. Only approximately 100 cases have been reported, and half of them were in China. Limited details about CCTLs often cause diagnostic or therapeutic problems.
We describe a case of a 28-year-old woman with multiple gradually replicating and enlarging nodules in the left lower lobe. The patient underwent fine-needle aspiration biopsy and was diagnosed with CCTL. A left lower lobectomy and mediastinal lymph node dissection were performed. The gradual changes in size (1.4 cm to 2.8 cm) and quantity (10 to 49) of the CCTLs in this case were the biggest differences from previously reported cases.
CCTLs are very uncommon and mostly benign PEComatous tumors with no specific morphologic features. We present a case of CCTL with multiplicity and rapid growth, which may indicate its aggressive nature. The accumulation of similar cases will help clarify the exact nature and improve our understanding of the disease.
肺透明细胞瘤（CCTLs）是罕见的，主要是起源于血管周上皮样细胞的良性肺肿瘤。仅约100例病例被报道，其中一半在中国。关于CCTLs的细节有限，常导致诊断或治疗问题。
我们描述了一名28岁女性病例，其左下叶有多个逐渐增大的结节。患者接受了细针穿刺活检，被诊断为CCTL。进行了左下叶切除术和纵隔淋巴结清扫术。该病例中CCTLs在大小（从1.4厘米至2.8厘米）和数量（从10个至49个）上的逐渐变化是与先前报道病例的最大差异。
CCTLs非常罕见，大多是无特定形态特征的良性PEComa肿瘤。我们呈现了一例具有多发性和快速生长的CCTL病例，这可能表明其侵袭性本质。类似病例的积累将有助于明确其确切性质并增进我们对该疾病的理解。
