Varol Muhammed, Arapi Berk, Tel Üstünışık Çiğdem, Göksedef Deniz, Ömeroğlu Suat Nail, İpek Gökhan, Balkanay Ozan Onur
Department of Cardiovascular Surgery, Mayo Clinic, Rochester, MN, USA.
Cerrahpasa Medical Faculty, Department of Cardiovascular Surgery, Istanbul University-Cerrahpasa, Istanbul, Turkey.
J Cardiothorac Surg. 2025 Jan 8;20(1):46. doi: 10.1186/s13019-024-03227-3.
Despite the advances in medicine, aortic dissection remains a cardiac surgery emergency with high mortality and morbidity rates. This study examined the effects of the Glue + Felt technique, which uses biological glue and felt to repair the proximal anastomotic site, on the outcomes of patients with acute type A aortic dissection.
A total of 108 patients who underwent surgery for acute type A aortic dissection at our clinic between 2007 and 2020 were included in the study. The patients were divided into two groups: the "Glue + Felt Technique" and the "Bentall-De Bono" groups, based on the surgical technique used for the aortic root. The effects of these two techniques on the development of intraoperative and postoperative complications and survival rates were statistically analyzed.
The Glue + Felt technique was used for 76 patients, while the Bentall-De Bono technique was used for 32 patients. The Kaplan-Meier analysis revealed significant differences in survival rates between the two groups over the entire follow-up period, both with and without propensity score matching (p < 0.001 and p = 0.02, respectively). However, no significant differences were observed in comparisons beyond the first 30 days of follow-up, either with or without propensity score matching (p = 0.573 and p = 0.561, respectively). The main factors contributing to this difference were the duration of cardiopulmonary bypass and aortic cross-clamp time (p < 0.05). During the average follow-up period of 46.2 ± 31.6 months, no re-intervention was required in patients from the Glue-Felt technique group.
The mortality rate in aortic dissection surgery is higher with more extensive surgical intervention as the duration of cardiopulmonary bypass and aortic cross-clamp time increases. Repairing the lumen and reducing operation time in suitable patients using the Glue-Felt technique for the proximal anastomotic site positively impacts postoperative complications and improves in-hospital and 30-day survival rates, without increasing long-term re-intervention rates.
尽管医学取得了进步,但主动脉夹层仍然是心脏外科的急症,死亡率和发病率都很高。本研究探讨了使用生物胶和毡片修复近端吻合口的胶水+毡片技术对急性A型主动脉夹层患者预后的影响。
本研究纳入了2007年至2020年间在我院接受急性A型主动脉夹层手术的108例患者。根据主动脉根部的手术技术,将患者分为两组:“胶水+毡片技术”组和“Bentall-De Bono”组。对这两种技术对术中及术后并发症发生情况和生存率的影响进行了统计学分析。
76例患者采用胶水+毡片技术,32例患者采用Bentall-De Bono技术。Kaplan-Meier分析显示,在整个随访期内,无论是否进行倾向得分匹配,两组的生存率均有显著差异(分别为p<0.001和p=0.02)。然而,在随访30天后的比较中,无论是否进行倾向得分匹配,均未观察到显著差异(分别为p=0.573和p=0.561)。造成这种差异的主要因素是体外循环时间和主动脉阻断时间(p<0.05)。在平均46.2±31.6个月的随访期内,胶水-毡片技术组患者无需再次干预。
随着体外循环时间和主动脉阻断时间的增加,主动脉夹层手术的死亡率会因手术干预范围扩大而升高。对于合适的患者,使用胶水-毡片技术修复近端吻合口以修复管腔并缩短手术时间,对术后并发症有积极影响,并可提高住院期间和30天生存率,且不会增加长期再次干预率。