Biomedical Research Unit of the Mexican Social Security Institute at Durango.
J Food Biochem. 2020 Sep;44(9):e13389. doi: 10.1111/jfbc.13389. Epub 2020 Jul 21.
We evaluate the hypoglycemic and antioxidant effects of five commercial turmeric (Curcuma longa) supplements: (1) bulk samples, (2) turmeric root from India, (3) curcuma turmeric Pronat , (4) turmeric & black pepper Swanson , and (5) C3 complex turmeric curcumin. Glucose diffusion and enzymatic starch digestion assays, using α-amylase and α-glucosidase, were performed. The antioxidant activity of turmeric supplements was measured through lipid peroxidation inhibition and the scavenging radical assay. A starch dose of 102 mg/Kg of body weight (equivalent to 1 g/day in humans) was used to perform the oral starch tolerance test (OSTT) in Wistar male rats. All turmeric supplements decreased glucose diffusion and α-glucosidase enzyme activity, and inhibited lipid peroxidation. The rats that received bulk samples and CT showed significantly lower glucose levels than rats receiving acarbose and those of negative control group. Our results show that biological activities of turmeric supplements vary according to the commercial presentation. PRACTICAL APPLICATIONS: The study results suggest that the hypoglycemic and antioxidant effects of five commercial turmeric supplements vary among them. The information provided would be useful to physicians and individuals using these supplements.
我们评估了五种商业姜黄(Curcuma longa)补充剂的降血糖和抗氧化作用:(1)散装样品,(2)来自印度的姜黄根,(3)curcuma turmeric Pronat,(4) turmeric & black pepper Swanson,和(5)C3 复合姜黄姜黄素。进行了葡萄糖扩散和使用α-淀粉酶和α-葡萄糖苷酶的淀粉消化酶促测定。通过脂质过氧化抑制和自由基清除测定法测量姜黄补充剂的抗氧化活性。使用 102mg/kg 体重的淀粉剂量(相当于人类每天 1g)在 Wistar 雄性大鼠中进行口服淀粉耐量试验(OSTT)。所有姜黄补充剂均降低了葡萄糖扩散和α-葡萄糖苷酶的酶活性,并抑制了脂质过氧化。与阿卡波糖组和阴性对照组相比,接受散装样品和 CT 的大鼠的血糖水平明显降低。我们的研究结果表明,商业展示形式的姜黄补充剂的生物活性不同。实际应用:研究结果表明,五种商业姜黄补充剂的降血糖和抗氧化作用各不相同。提供的信息对使用这些补充剂的医生和个人将非常有用。