Ekiti State University, Ado Ekiti, Nigeria.
J Food Biochem. 2022 Jan;46(1):e14019. doi: 10.1111/jfbc.14019. Epub 2021 Nov 24.
Effects of various concentration of turmeric (Curcuma longa [C longa]) rhizome powder (TRP) supplemented diet on the antioxidant status of selected organs (stomach, liver, kidney, and heart) of indomethacin (Indo)-induced ulcerated wistar rats were investigated in this study. The rats were fed with different percentages of TRP supplemented diet (1% [A], 2% [B], 5% [C], and 10% [D]) for 28 days. It was observed from the results that animals fed on 10% turmeric rhizome supplemented and those in the ulcerogenic group had significant reduction in kidney, cardiac gluthione (GSH), superoxide dismutase (SOD), catalase (CAT), and gastric GSH when compared with normal control animals and other pre-treated groups. However, a significant increase was observed in gastric, hepatic, cardiac, and glutathione peroxidase (GPX); kidney and hepatic SOD; cardiac, kidney, hepatic, and gastric CAT of animals pre- treated with TRP supplemented diet (1%-5%) compared with ulcerogenic group. Also, a significant reduction was observed in GPX of animals fed with 10% TRP supplemented diet in comparison with ulcerogenic group. Consumption of TRP in the diet, therefore, should be lesser than 10% of the whole recipe for it to be potent in enhancing antioxidant defensive mechanism of the aforementioned organs and thereby prevent oxidative stress related diseases. It may reduce antioxidant present in those organs which can lead to increase availability of free radical and expose the organs to oxidative stress-related diseases. PRACTICAL APPLICATIONS: Inclusion of turmeric rhizome powder in daily diet has been globally well accepted due to the knowledge of its medicinal values. Nonetheless, the extent at which it should be consumed has been controversial and unclear. Little or no effort has been put in place to educate the populace on the quantity of concentration of C. longa powder which should be in whole recipe or ingredients. Therefore, if turmeric rhizome powder should be included in diet because of its nutritional and medicinal values, this should be with caution and from the results of this study, the concentration should not be up to 100g/kg w/w of the entire recipe.
本研究旨在探讨不同浓度姜黄（Curcuma longa [C longa]）根茎粉（TRP）补充饮食对消炎痛（Indo）诱导溃疡的 Wistar 大鼠选定器官（胃、肝、肾和心脏）抗氧化状态的影响。大鼠连续 28 天分别喂食不同百分比的 TRP 补充饮食（1%[A]、2%[B]、5%[C]和 10%[D]）。结果表明，与正常对照组和其他预处理组相比，喂食 10%姜黄根茎补充饮食和溃疡组的动物的肾脏、心脏谷胱甘肽（GSH）、超氧化物歧化酶（SOD）、过氧化氢酶（CAT）和胃 GSH 显著减少。然而，与溃疡组相比，喂食 TRP 补充饮食（1%-5%）的动物的胃、肝、心脏和谷胱甘肽过氧化物酶（GPX）；肾脏和肝脏 SOD；心脏、肾脏、肝脏和胃 CAT 显著增加。此外，与溃疡组相比，喂食 10%TRP 补充饮食的动物的 GPX 显著减少。因此，饮食中 TRP 的摄入量应小于整个配方的 10%，才能有效增强上述器官的抗氧化防御机制，从而预防与氧化应激相关的疾病。它可能会减少这些器官中存在的抗氧化剂，从而增加自由基的可用性，并使器官易患与氧化应激相关的疾病。实际应用：由于了解其药用价值，姜黄根茎粉已在全球范围内被广泛接受作为日常饮食的一部分。尽管如此，其摄入量应该是多少一直存在争议和不清楚。人们很少或根本没有努力让民众了解整个配方或成分中 C. longa 粉末的浓度应该是多少。因此，如果由于其营养价值和药用价值而将姜黄根茎粉纳入饮食，应谨慎行事，根据本研究的结果，浓度不应达到整个配方的 100g/kg w/w。
