Abbasi-Maleki Saeid, Kadkhoda Zohre, Taghizad-Farid Rahim
Department of Pharmacology & Toxicology, Urmia Branch, Islamic Azad University, Urmia, Iran.
Research Development and Training Center, Adonis Gol Darou Pharmaceutical Co., Tehran, Iran.
J Tradit Complement Med. 2019 Jan 14;10(4):327-335. doi: 10.1016/j.jtcme.2019.01.003. eCollection 2020 Jul.
L is an herb used in the treatment of diseases related to the nervous system in traditional medicine (e.g. as an anticonvulsant and sedative). The present study was conducted to investigate the antidepressant-like effects of essential oil (OMEO) on mice in the forced swimming test (FST). The animals were intraperitoneally (i.p.) injected with OMEO (10-80 mg/kg) 1 h before the FST. To assess the involvement of the monoaminergic system in the antidepressant activity of OMEO, different pharmacological antagonists were administered 15 min before OMEO administration (80 mg/kg). The administration of OMEO (40 and 80 mg/kg, i.p.) decreased immobility time and increased swimming and climbing times significantly. OMEO did not cause any changes in spontaneous locomotor function in the open-field test (OFT). The pre-treatment of the animals with SCH23390, sulpiride, haloperidol, WAY100135, -chlorophenylalanine (pCPA), ketanserin, prazosin, yohimbine, reserpine, but propranolol, inhibited the anti-immobility effect of OMEO in the FST. A combination of sub-effective doses of fluoxetine (5 mg/kg, i.p.) or imipramine (5 mg/kg, i.p.) with OMEO (10 mg/kg, i.p.) increased the antidepressant-like effects. OMEO showed antidepressant-like effects through involvement with the dopaminergic (D and D), serotonergic (5HT1, 5-HT2 receptors) and noradrenergic (α and α adrenoceptors) systems.
L是一种在传统医学中用于治疗与神经系统相关疾病的草药（例如作为抗惊厥药和镇静剂）。本研究旨在探讨精油（OMEO）在强迫游泳试验（FST）中对小鼠的抗抑郁样作用。在FST前1小时，给动物腹腔注射OMEO（10 - 80mg/kg）。为了评估单胺能系统在OMEO抗抑郁活性中的作用，在注射OMEO（80mg/kg）前15分钟给予不同的药理拮抗剂。腹腔注射OMEO（40和80mg/kg）可显著减少不动时间，增加游泳和攀爬时间。在旷场试验（OFT）中，OMEO对自发运动功能没有任何影响。用SCH23390、舒必利、氟哌啶醇、WAY100135、对氯苯丙氨酸（pCPA）、酮色林、哌唑嗪、育亨宾、利血平预处理动物，但普萘洛尔抑制了OMEO在FST中的抗不动作用。亚有效剂量的氟西汀（5mg/kg，腹腔注射）或丙咪嗪（5mg/kg，腹腔注射）与OMEO（10mg/kg，腹腔注射）联合使用可增强抗抑郁样作用。OMEO通过涉及多巴胺能（D1和D2）、5-羟色胺能（5-HT1、5-HT2受体）和去甲肾上腺素能（α1和α2肾上腺素能受体）系统表现出抗抑郁样作用。
