Hsu Chia-Yun, Lin Gong-Min, Chang Shang-Tzen
School of Forestry and Resource Conservation, National Taiwan University, #1, Sec. 4, Roosevelt Rd., Taipei, 10617, Taiwan.
J Tradit Complement Med. 2019 Nov 29;10(4):389-395. doi: 10.1016/j.jtcme.2019.11.003. eCollection 2020 Jul.
var. is a species indigenous to Taiwan and has been used as a medicinal plant. It has been claimed that the hot water extracts of var. leaves (CoLE) with flavonoids and proanthocyanidins have anti-oxidant and anti-hyperglycemic activities . This study further examines the anti-hyperglycemic activity of CoLE and its possible mechanisms in hyperglycemic rats. Hyperglycemia of rats was induced by streptozotocin (STZ) and high-fat diets (HFD). Hyperglycemic rats treated orally with 30 and 150 mg/kg CoLE were classified into LCO and HCO groups, respectively. After three-month treatment, both LCO and HCO groups showed improved glucose metabolism in oral glucose tolerance and postprandial blood glucose tests. Decrease in HOMA-IR, leptin and adiponectin levels of the HCO group revealed amelioration of insulin and leptin resistance. Obesity and accumulation of visceral fats induced by STZ and HFD could be alleviated in both HCO and LCO groups. These anti-diabetic effects might be contributed by inhibition of intestinal digested enzymes and protein tyrosine phosphatases (PTPases). Although other studies are necessary, these findings suggest that CoLE could be potentially used as a health complement for treating diabetes without significant toxicity.
变种是台湾本土的一种植物，一直被用作药用植物。据称，含有黄酮类化合物和原花青素的变种叶热水提取物（CoLE）具有抗氧化和降血糖活性。本研究进一步考察了CoLE在高血糖大鼠中的降血糖活性及其可能机制。通过链脲佐菌素（STZ）和高脂饮食（HFD）诱导大鼠高血糖。分别以30和150mg/kg CoLE口服治疗的高血糖大鼠被分为低剂量CoLE组（LCO）和高剂量CoLE组（HCO）。经过三个月的治疗，LCO组和HCO组在口服葡萄糖耐量和餐后血糖测试中均显示出葡萄糖代谢改善。HCO组的胰岛素抵抗指数（HOMA-IR）、瘦素和脂联素水平降低，表明胰岛素和瘦素抵抗得到改善。HCO组和LCO组均可减轻由STZ和HFD诱导的肥胖和内脏脂肪堆积。这些抗糖尿病作用可能是通过抑制肠道消化酶和蛋白酪氨酸磷酸酶（PTPases）实现的。尽管还需要其他研究，但这些发现表明，CoLE可能有潜力作为一种健康补充剂用于治疗糖尿病，且无明显毒性。
