Department of Biomedical Sciences, University of Padua, Padua, Italy.
CNR Institute of Neuroscience, Padua, Italy.
Methods Mol Biol. 2020;2141:127-143. doi: 10.1007/978-1-0716-0524-0_6.
Nowadays, it is well established that many proteins or regions under physiological conditions lack a fixed three-dimensional structure and are intrinsically disordered. MobiDB is the main repository of protein disorder and mobility annotations, combining different data sources to provide an exhaustive overview of intrinsic disorder. MobiDB includes curated annotations from other databases, indirect disorder evidence from structural data, and disorder predictions from protein sequences. It provides an easy-to-use web server to visualize and explore disorder information. This chapter describes the data available in MobiDB, emphasizing how to use and access the intrinsic disorder data. MobiDB is available at URL http://mobidb.bio.unipd.it .
如今，人们已经充分认识到，在生理条件下，许多蛋白质或区域缺乏固定的三维结构，而是固有地无序。MobiDB 是蛋白质无序和迁移注释的主要存储库，它结合了不同的数据源，提供了对内在无序的详尽概述。MobiDB 包括来自其他数据库的精心注释、来自结构数据的间接无序证据以及来自蛋白质序列的无序预测。它提供了一个易于使用的网络服务器，用于可视化和探索无序信息。本章介绍了 MobiDB 中的可用数据，重点介绍了如何使用和访问内在无序数据。MobiDB 可在 URL http://mobidb.bio.unipd.it 获得。
