Universidade Estadual de Ciências da Saúde de Alagoas, Maceió, Brazil.
Universidade Federal de Sergipe, Aracajú, Brazil.
Cad Saude Publica. 2020;36(7):e00087320. doi: 10.1590/0102-311x00087320. Epub 2020 Jul 17.
In less than four months, the total of confirmed cases of COVID-19 was 1,684,833 worldwide. Outcomes among the public of pregnant women with COVID-19 are still unclear. We performed a systematic review and meta-analysis to analyze whether COVID-19 in pregnant women is related to premature birth and birth weight, and to summarize the diagnostic results of neonates born to mothers with COVID-19 for investigating the possibility of vertical transmission. Searches were performed in PubMed, Scopus, LILACS, Web of Science, Google Scholar, Preprints, bioRxiv, and medRxiv. We used the odds ratio (OR) and mean difference (MD) as measure of analysis. Summary estimates were calculated using random effects models. 38 studies were included; data from 279 women were analyzed; 60 patients were diagnosed with COVID-19. The meta-analysis showed no significant association between COVID-19 and preterm delivery (OR = 2.25; 95%CI: 0.96, 5.31; p = 0.06; I² = 0%). No significant relationship was found between birth weight and COVID-19 (MD = -124.16; 95%CI: -260.54, 12.22; p = 0.07; I² = 0%). Among 432 newborns, 10 were reported with positive results for early SARS-CoV-2. Due to the characteristics of the studies, the level of evidence of this meta-analysis was considered very low. COVID-19 in pregnant women may not be associated with the occurrence of preterm deliveries or the birth weight of the newborn children, however the evidence to date is very uncertain. A few reports suggest vertical transmission of SARS-CoV-2 to newborn is possible, but evidence is still uncertain.
在不到四个月的时间里，全球 COVID-19 确诊病例总数达到 1,684,833 例。公众对 COVID-19 孕妇的结局仍不清楚。我们进行了系统评价和荟萃分析，以分析 COVID-19 孕妇是否与早产和新生儿出生体重有关，并总结 COVID-19 母亲所生新生儿的诊断结果，以调查垂直传播的可能性。在 PubMed、Scopus、LILACS、Web of Science、Google Scholar、Preprints、bioRxiv 和 medRxiv 中进行了检索。我们使用优势比 (OR) 和均数差 (MD) 作为分析测量。使用随机效应模型计算汇总估计值。纳入 38 项研究；对 279 名妇女的数据进行了分析；60 名患者被诊断患有 COVID-19。荟萃分析显示 COVID-19 与早产无显著相关性（OR=2.25；95%CI：0.96，5.31；p=0.06；I²=0%）。出生体重与 COVID-19 之间未发现显著关系（MD=-124.16；95%CI：-260.54，12.22；p=0.07；I²=0%）。在 432 名新生儿中，有 10 名被报告 SARS-CoV-2 早期检测结果呈阳性。由于研究的特点，本荟萃分析的证据水平被认为非常低。COVID-19 孕妇的发生可能与早产或新生儿出生体重无关，但目前的证据非常不确定。一些报告表明 SARS-CoV-2 垂直传播给新生儿是可能的，但证据仍不确定。
