Human Health and National Deuteration Facility (NDF), Australian Nuclear Science and Technology Organisation (ANSTO), New Illawarra Road, Lucas Heights, NSW, 2234, Australia.
School of Molecular and Life Sciences, Curtin University, Kent Street, Bentley, WA, 6102, Australia.
Chemistry. 2021 Jan 13;27(3):861-876. doi: 10.1002/chem.202001402. Epub 2020 Nov 9.
Positron emission tomography (PET)-fluorescence imaging is an emerging field of multimodality imaging seeking to attain synergy between the two techniques. The probes employed in PET-fluorescence imaging incorporate both a fluorophore and radioisotope which enable complementary information to be obtained from both imaging techniques via the administration of a single agent. Fluorine-18 is the most commonly used radioisotope in PET imaging and consequently many novel attempts to radiofluorinate various fluorophores have transpired over the past decade. In this Minireview, the most relevant fluorine-18 labelled PET-fluorescence probes have been classified into four groups as per the implemented fluorophore: 1) boron-dipyrromethene (BODIPY) dyes, 2) cyanine dyes, 3) alternative organic fluorophores and 4) organometallics, such as quantum dots (QDs) and rhenium complexes. The biological, radiochemical and photophysical properties of each probe have been systematically compared to aid future endeavours in PET-fluorescence chemistry.
正电子发射断层扫描（PET）-荧光成像是一种新兴的多模态成像领域，旨在实现两种技术的协同作用。在 PET-荧光成像中使用的探针既包含荧光团又包含放射性同位素，这使得通过施用单一试剂可以从两种成像技术获得互补信息。氟-18 是 PET 成像中最常用的放射性同位素，因此在过去十年中，许多新型尝试对各种荧光团进行放射性标记已经出现。在这篇综述中，根据所使用的荧光团，将最相关的氟-18 标记的 PET-荧光探针分为四类：1）硼二吡咯甲川（BODIPY）染料，2）花菁染料，3）替代有机荧光团，4）金属有机化合物，如量子点（QD）和铼配合物。对每个探针的生物学、放射化学和光物理性质进行了系统比较，以帮助未来的 PET-荧光化学研究。
