Department of Internal Medicine and Oncological Chemotherapy, Medical University of SilesiaKatowice40-027, Poland.
Acta Pharm. 2021 Mar 1;71(1):1-16. doi: 10.2478/acph-2021-0007.
Substances available in nature with potential therapeutic effects are the subject of research that raises tremendous hopes for new challenges in medicine. Fungi are the most common organisms in the ecosystem and the most interesting in this respect. This review discusses two species of edible fungi, used for centuries in Eastern natural medicine, with the best-documented effect - Hericium erinaceus (He) and Trametes versicolor (Tv). The results of in vivo and in vitro studies conducted on mice and human cell lines demonstrate immunomodulatory, potentially, anticancer, anti-inflammatory and neuroregenerative effects of substances isolated from these fungi. The substances contained in the extracts of He and Tv seem to have immunomodulatory effects that may support chemotherapy. The use of these extracts is justified stronger than the other supportive treat ments based on supplements.
自然界中具有潜在治疗效果的物质是研究的主题，为医学的新挑战带来了巨大的希望。真菌是生态系统中最常见的生物，在这方面最有趣。本文讨论了两种在东方天然药物中使用了几个世纪的可食用真菌，它们具有最好记录的效果——珊瑚菌（He）和云芝（Tv）。在小鼠和人细胞系上进行的体内和体外研究的结果表明，从这些真菌中分离出的物质具有免疫调节、潜在的抗癌、抗炎和神经再生作用。He 和 Tv 提取物中含有的物质似乎具有免疫调节作用，可以支持化疗。与基于补充剂的其他支持性治疗相比，使用这些提取物更有理由。
