Sculean Anton, Alessandri Regina, Miron Richard, Salvi Giovanni E, Bosshardt Dieter D
Department of Periodontology, School of Dental Medicine, University of Bern, Bern, Switzerland.
Department of Oral Surgery and Stomatology, School of Dental Medicine, University of Bern.
Clin Adv Periodontics. 2011 Aug;1(2):101-117. doi: 10.1902/cap.2011.110047.
The goal of regenerative periodontal therapy is the reconstitution of lost periodontal structures (i.e., the new formation of root cementum, periodontal ligament, and alveolar bone). Results from preclinical and clinical research in the last decade have provided evidence on the biologic rationale and clinical applications of an enamel matrix derivative (EMD) protein in periodontal wound healing and regeneration. Case Presentations and Literature Overview: This paper will provide an overview of the biologic rationale for using enamel matrix proteins (EMPs) in regenerative periodontal therapy. Based on the available preclinical and clinical evidence, the main clinical indications for using EMD in regenerative periodontal therapy will be discussed.
The available data provide evidence of the biologic rationale of EMPs to support periodontal wound healing and regeneration. The application of EMD in conjunction with a surgical access may result in substantial regeneration of root cementum, periodontal ligament, and bone, thus improving the clinical outcomes in intrabony, recession, and Class II furcation defects.
再生性牙周治疗的目标是重建缺失的牙周结构（即新形成牙根骨质、牙周韧带和牙槽骨）。过去十年的临床前和临床研究结果为釉基质衍生物（EMD）蛋白在牙周伤口愈合和再生中的生物学原理及临床应用提供了证据。病例展示与文献综述：本文将概述在再生性牙周治疗中使用釉基质蛋白（EMPs）的生物学原理。基于现有的临床前和临床证据，将讨论在再生性牙周治疗中使用EMD的主要临床适应症。
现有数据为EMPs支持牙周伤口愈合和再生的生物学原理提供了证据。EMD与手术入路联合应用可能会使牙根骨质、牙周韧带和骨大量再生，从而改善骨内、退缩和II度根分叉病变的临床疗效。
