Department of Bioregulation and Pharmacological Medicine, Fukushima Medical University , Fukushima, Japan.
Graduate School of Agricultural Science, Tohoku University , Sendai, Japan.
Biosci Biotechnol Biochem. 2020 Nov;84(11):2207-2214. doi: 10.1080/09168451.2020.1794783. Epub 2020 Jul 22.
Resveratrol (RSV) is a natural polyphenol present in grapes, the skin of peanuts, and several other plants with many health benefits. Autism spectrum disorder (ASD) is a neurodevelopmental disorder that may be linked to neural and synaptic development impairments. The present study aimed to analyze the preventive effects of RSV on the development of ASD-like behavior, using knockout (-KO) and valproic acid-induced ASD (VPA-ASD) model mice. Genetic deficiencies in are suggested to be involved in ASD etiology. Twenty-four hours after a single RSV injection to the -KO mice, the social impairments caused by OXTR deficiency were ameliorated. RSV also improved social impairments in the VPA-ASD mice. Administration of RSV up-regulated ( gene and () gene expressions in the amygdala of the -KO mice. Our data suggest that RSV may have therapeutic effects on ASD with multiple targets.
白藜芦醇（RSV）是一种天然多酚，存在于葡萄、花生的外皮和其他几种植物中，具有许多健康益处。自闭症谱系障碍（ASD）是一种神经发育障碍，可能与神经和突触发育障碍有关。本研究旨在分析 RSV 对 ASD 样行为发展的预防作用，使用 敲除（-KO）和丙戊酸诱导的 ASD（VPA-ASD）模型小鼠。 基因的遗传缺陷被认为与 ASD 的病因有关。在对 -KO 小鼠单次 RSV 注射 24 小时后，OXTR 缺乏引起的社交障碍得到改善。RSV 还改善了 VPA-ASD 小鼠的社交障碍。RSV 的给药上调了 -KO 小鼠杏仁核中的 （基因和 （）基因表达。我们的数据表明，RSV 可能对具有多种靶点的 ASD 具有治疗作用。
