免疫抑制对两名肾移植受者抗 SARS-CoV-2 血清转化的影响。
Influence of immunosuppression on seroconversion against SARS-CoV-2 in two kidney transplant recipients.
机构信息
Division of Nephrology, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Division of Infectious Diseases and Geographic Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.
出版信息
Transpl Infect Dis. 2021 Feb;23(1):e13423. doi: 10.1111/tid.13423. Epub 2020 Aug 8.
Abstract
Solid organ transplant recipients are at risk for infectious complications due to chronic immunosuppression. The outbreak of coronavirus disease 2019 (COVID-19) in the United States has raised growing concerns for the transplant patient population. We seek to add to the current limited literature on COVID-19 in transplant recipients by describing the clinical course of two kidney transplant recipients with SARS-CoV-2 infection monitored by both RT-PCR and serology. Through careful adjustment of their immunosuppression regimen, both patients had excellent recovery with intact graft function and development of anti-SARS-CoV-2 antibodies.
摘要
实体器官移植受者由于慢性免疫抑制而面临感染并发症的风险。2019 年冠状病毒病（COVID-19）在美国的爆发引起了人们对移植患者群体的日益关注。我们试图通过描述 2 例接受 SARS-CoV-2 感染的肾移植受者的临床过程，对目前有限的关于 COVID-19 在移植受者中的文献进行补充，这 2 例患者均通过 RT-PCR 和血清学进行监测。通过仔细调整他们的免疫抑制方案，这 2 例患者都恢复得很好，移植物功能完好，并产生了抗 SARS-CoV-2 抗体。
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