Department of Urology, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria.
Department of Urology, Clinique Pasteur, Toulouse, France.
Curr Opin Urol. 2020 Sep;30(5):735-739. doi: 10.1097/MOU.0000000000000808.
Despite the plethora of publications discussing the severe respiratory coronavirus 2 (SARS-CoV-2), evidence of viral secretion in urine is sparse.
We could identify 34 publications including a total of 2172 patients. Among those, 549 patients were tested for SARS-CoV-2 secretion in urine, which was detected in only 38 patients (6.9%). Within the seven studies displaying positive results, the majority of positive patients (86.8%) was from not yet peer-reviewed studies including weak data and heterogeneous techniques for sample testing. Furthermore, none of the studies available in the literature addressed the virulence of detected viral RNA in urine.
Overall, only seven studies were able to detect SARS-CoV-2 secretion in urine, all of them with a considerably low rate of positivity. However, these studies were of rather low quality considering their methodology. Despite this, as SARS-CoV-2 has been detected in urine, it is of importance to discuss safety and urinary hygiene protocols. Until further research provides valid data on viral shedding and virulence in urine, potential risk of transmission through urine cannot be ruled out. Therefore, safety and hygiene measures need to be discussed.
尽管有大量关于严重呼吸冠状病毒 2（SARS-CoV-2）的出版物，但关于病毒在尿液中分泌的证据很少。
我们可以识别出 34 篇出版物，其中包括总共 2172 名患者。在这些患者中，有 549 名患者的尿液中检测到 SARS-CoV-2 分泌物，只有 38 名患者（6.9%）检测到阳性。在显示阳性结果的七项研究中，大多数阳性患者（86.8%）来自尚未经过同行评审的研究，包括数据薄弱和样本检测技术异质性。此外，文献中没有一项研究涉及尿液中检测到的病毒 RNA 的毒力。
总体而言，只有 7 项研究能够检测到 SARS-CoV-2 在尿液中的分泌，所有这些研究的阳性率都相当低。然而，考虑到这些研究的方法，它们的质量相当低。尽管如此，由于已经在尿液中检测到 SARS-CoV-2，因此讨论安全性和尿液卫生方案很重要。在进一步的研究提供有关病毒在尿液中的脱落和毒力的有效数据之前，不能排除通过尿液传播的潜在风险。因此，需要讨论安全和卫生措施。
