Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, People's Republic of China.
Department of Clinical Laboratory, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, People's Republic of China.
Clin Infect Dis. 2020 Jul 28;71(15):813-817. doi: 10.1093/cid/ciaa375.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is spread mainly through respiratory droplets or direct contact. However, the infection condition of the genital system is unknown. Our aim in this study was to determine if SARS-CoV-2 is present in the vaginal fluid of women with coronavirus disease 2019 (COVID-19).
Ten women with confirmed severe COVID-19 pneumonia admitted to the Tongji Zhongfa Hospital intensive care unit from 4 February 2020 through 24 February 2020 were included. Clinical records, laboratory results, and computed tomography examinations were retrospectively reviewed. The potential for genital infection was accessed by testing for the presence of SARS-CoV-2 in vaginal fluids obtained from vaginal swab samples. Reverse transcriptase polymerase chain reaction was used to confirm the SARS-CoV-2 infection in vaginal fluids.
The clinical characteristics of the 10 women were similar to those reported in other severe COVID-19 patients. All 10 patients were tested for SARS-CoV-2 in vaginal fluid, and all samples tested negative for the virus.
Findings from this small group of cases suggest that SARS-CoV-2 virus does not exist in the vaginal fluids of severe COVID-19 patients.
严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）主要通过呼吸道飞沫或直接接触传播。然而，生殖器系统的感染情况尚不清楚。本研究旨在确定 2019 年冠状病毒病（COVID-19）女性的阴道液中是否存在 SARS-CoV-2。
纳入 2020 年 2 月 4 日至 2 月 24 日期间，10 名确诊为严重 COVID-19 肺炎的女性患者，她们均入住同济中法医院重症监护病房。回顾性分析了临床记录、实验室结果和计算机断层扫描检查。通过检测阴道拭子样本中阴道液中 SARS-CoV-2 的存在，评估潜在的生殖器感染情况。采用逆转录聚合酶链反应（RT-PCR）对阴道液中的 SARS-CoV-2 感染进行确认。
10 名女性的临床特征与其他严重 COVID-19 患者相似。对所有 10 名患者进行了阴道液中 SARS-CoV-2 的检测，所有样本均检测为病毒阴性。
该小样本病例研究结果提示，SARS-CoV-2 病毒不存在于严重 COVID-19 患者的阴道液中。
