Bae J M, Kim Y-S, Choo E H, Kim M-Y, Lee J Y, Kim H-O, Park Y M
Department of Dermatology, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Department of Microbiology, College of Medicine, The Catholic University of Korea, Seoul, Korea.
J Eur Acad Dermatol Venereol. 2021 Jan;35(1):222-229. doi: 10.1111/jdv.16830. Epub 2020 Aug 17.
Systemic effects of long-term narrowband ultraviolet B (NB-UVB) phototherapy have not been well studied in vitiligo patients. An 11-year nationwide population-based retrospective cohort study was conducted using the Korean National Health Insurance claims database (2007-2017).
To investigate the effects of long-term NB-UVB phototherapy on the risk of cardiovascular and cerebrovascular events in vitiligo patients.
This study included vitiligo patients with ≥100 phototherapy sessions (phototherapy group, n = 3229) and <3 phototherapy sessions (no phototherapy group, n = 9687), in which covariables with age, sex, insurance type and comorbidities such as diabetes, hypertension and hyperlipidemia were matched by 1 : 3 propensity score matching. The outcomes of interest were cardiovascular (ischaemic heart disease and myocardial infarction) and cerebrovascular events (cerebrovascular infraction and haemorrhage). Cox proportional hazards models were used to assess the associations between NB-UVB phototherapy and each event.
The risk of cardiovascular or cerebrovascular events was significantly decreased in the phototherapy group compared with the no phototherapy group [hazard ratio (HR) 0.637, 95% confidence interval (CI) 0.523-0.776]. Subgroup analysis revealed that the risk of cardiovascular (HR: 0.682, 95% CI: 0.495-0.940) and cerebrovascular events (HR: 0.601, 95% CI: 0.470-0.769) were significantly lower in the phototherapy group than the no phototherapy group, respectively.
Our findings suggest that long-term NB-UVB phototherapy could decrease the risk of cardiovascular and cerebrovascular events in patients with vitiligo.
长期窄谱中波紫外线（NB-UVB）光疗对白癜风患者的全身影响尚未得到充分研究。我们利用韩国国民健康保险索赔数据库（2007 - 2017年）进行了一项为期11年的全国性基于人群的回顾性队列研究。
探讨长期NB-UVB光疗对白癜风患者发生心血管和脑血管事件风险的影响。
本研究纳入了接受≥100次光疗的白癜风患者（光疗组，n = 3229）和接受<3次光疗的患者（无光疗组，n = 9687），通过1:3倾向评分匹配对年龄、性别、保险类型以及糖尿病、高血压和高脂血症等合并症的协变量进行匹配。感兴趣的结局是心血管事件（缺血性心脏病和心肌梗死）和脑血管事件（脑血管梗死和出血）。采用Cox比例风险模型评估NB-UVB光疗与每种事件之间的关联。
与无光疗组相比，光疗组发生心血管或脑血管事件的风险显著降低[风险比（HR）0.637，95%置信区间（CI）0.523 - 0.776]。亚组分析显示，光疗组心血管事件（HR：0.682，95% CI：0.495 - 0.940）和脑血管事件（HR：0.601，95% CI：0.470 - 0.769）的风险分别显著低于无光疗组。
我们的研究结果表明，长期NB-UVB光疗可降低白癜风患者发生心血管和脑血管事件的风险。
