Horrom N J, Brown C C
J Pharm Sci. 1977 May;66(5):739-41. doi: 10.1002/jps.2600660537.
Twenty normal, nonobese subjects (10 males and 10 female) were administered a battery of seven psychomotor tests as well as affect checklists and physiological measurements on 6 alternate days. Subjects performed the entire battery predrug and at 45,90, and 135 min postdrug. Fenfluramine, dextroamphetamine, two combined doses of the drugs, and a placebo were given in a double-blind, repeated measures design. Findings revealed significant sex-based differences in initial performance on five of the seven psychomotor tasks and in two physiological measures, with males performing at higher levels than females. Additionally, sex differences in postdrug changes were found in three psychomotor and two physiological measures, with females evidencing greater change scores than males.
20名正常、非肥胖受试者（10名男性和10名女性）在6个交替日接受了一系列7项心理运动测试、情感清单和生理测量。受试者在用药前以及用药后45分钟、90分钟和135分钟完成了全部测试。氟苯丙胺、右旋苯丙胺、两种药物组合剂量以及一种安慰剂采用双盲、重复测量设计给药。研究结果显示，在7项心理运动任务中的5项以及两项生理测量的初始表现上存在显著的性别差异，男性表现水平高于女性。此外，在三项心理运动和两项生理测量中发现了用药后变化的性别差异，女性的变化得分高于男性。
