ICMUB Institute (Chemistry Department) Sciences Mirande, Université de Bourgogne Franche Comté, 9 Avenue Alain Savary, Dijon 21078, France.
Centre George François Leclerc, 1 rue du Professeur Marion, Dijon 21079, France.
J Med Chem. 2020 Sep 10;63(17):9446-9456. doi: 10.1021/acs.jmedchem.0c00625. Epub 2020 Aug 10.
Cherenkov radiation (CR), the blue light seen in nuclear reactors, is emitted by some radiopharmaceuticals. This study showed that (1) a portion of CR could be transferred in the region of the optical spectrum, where biological tissues are most transparent: as a result, upon radiance amplification in the near-infrared window, the detection of light could occur twice deeper in tissues than during classical Cherenkov luminescence imaging and (2) Cherenkov-photodynamic therapy (CR-PDT) on cells could be achieved under conditions mimicking unlimited depth using the CR-embarked light source, which is unlike standard PDT, where light penetration depth is limited in biological tissues. Both results are of utmost importance for simultaneous applications in tumor resection and post-resection treatment of remaining unresected margins, thanks to a molecular construct designed to raise its light collection efficiency ( CR energy transfer) by conjugation with multiple CR-absorbing (water-soluble) antenna followed by intramolecular-FRET/TBET energy transfers.
切伦科夫辐射（CR），即核反应堆中可见的蓝光，是由一些放射性药物发射的。本研究表明：(1)CR 的一部分可以在光学光谱的区域内转移，该区域是生物组织最透明的区域：因此，在近红外窗口进行辐射放大时，与经典切伦科夫发光成像相比，光的检测可以深入组织两倍；(2)可以在模拟无限深度的条件下对细胞进行切伦科夫光动力治疗（CR-PDT），这与标准 PDT 不同，标准 PDT 中光的穿透深度在生物组织中是有限的。这两个结果都非常重要，因为通过设计一种分子结构，通过与多个 CR 吸收（水溶性）天线缀合来提高其光收集效率（CR 能量转移），然后进行分子内 FRET/TBET 能量转移，为肿瘤切除和剩余未切除边缘的术后治疗的同时应用提供了可能。
