Timpawat S, Amornchat C, Suriyaguntanone P
J Dent Assoc Thai. 1988 Jul-Aug;38(4):153-62.
This clinical and laboratory study was to compare the antimicrobial effects of camphorated monoparachlorophenol, Cresophene and formocresol. Root canals of anterior teeth with 3-5 mm. rarefied area were instrumented and irrigated until they were ready to be filled. The patients returned every 7 days. Intracanal medicaments were changed until negative culture was obtained. The number of visits was recorded. The comparative effectiveness of the three medicaments were analysed. Results showed no statistical differences of the three medicaments (p greater than 0.1). The antimicrobial activity against bacteria from positive root canal culture of these three antiseptics were assayed by disc diffusion method. The inhibition zone of camphorated mono-parachlorophenol and Cresophene were nearly the same size, but that of formocresol had greater diameter. Using Gram's staining procedure, the majority of bacteria obtained from root canals was identified as gram positive cocci (94.74%).
这项临床和实验室研究旨在比较樟脑对氯苯酚、甲酚间苯二酚和甲醛甲酚的抗菌效果。对根尖有3 - 5毫米稀疏区的前牙根管进行预备和冲洗,直至准备好充填。患者每7天复诊一次。更换根管内药物,直至获得阴性培养结果。记录就诊次数。分析三种药物的相对有效性。结果显示三种药物之间无统计学差异(p大于0.1)。采用纸片扩散法测定这三种防腐剂对根管阳性培养细菌的抗菌活性。樟脑对氯苯酚和甲酚间苯二酚的抑菌圈大小几乎相同,但甲醛甲酚的抑菌圈直径更大。采用革兰氏染色法,从根管中分离出的大多数细菌被鉴定为革兰氏阳性球菌(94.74%)。