Barbosa C A, Gonçalves R B, Siqueira J F, De Uzeda M
Department of Endodontics, Federal University of Rio de Janeiro, Brazil.
J Endod. 1997 May;23(5):297-300. doi: 10.1016/S0099-2399(97)80409-8.
The antibacterial activities of camphorated paramonochlorophenol, chlorhexidine, and calcium hydroxide were compared using a clinical and laboratory evaluation. In the clinical experiment, root canals that yielded positive cultures a week after complete chemomechanical preparation and camphorated paramonochlorophenol dressing were medicated with one of the three substances tested. Postmedication samples were taken from the canal 1 week later. In the laboratory experiment, the agar diffusion test was used to evaluate the inhibitory activity of the medicaments against bacteria commonly found in endodontic infections. The results of the clinical evaluation showed that all medicaments were effective in reducing or eliminating the endodontic microbiota, as demonstrated by the incidence of negative cultures. There was no statistically significant difference among the medicaments tested. In the laboratory evaluation, camphorated paramonochlorophenol showed the largest zones of bacterial inhibition against all bacterial strains tested.
使用临床和实验室评估比较了樟脑对氯苯酚、氯己定和氢氧化钙的抗菌活性。在临床实验中，对于在完成化学机械预备和樟脑对氯苯酚封药一周后培养结果呈阳性的根管，用三种受试物质之一进行治疗。治疗一周后从根管中采集用药后的样本。在实验室实验中，采用琼脂扩散试验评估药物对牙髓感染中常见细菌的抑制活性。临床评估结果表明，所有药物在减少或消除牙髓微生物群方面均有效，阴性培养的发生率证明了这一点。受试药物之间无统计学显著差异。在实验室评估中，樟脑对氯苯酚对所有受试菌株显示出最大的抑菌圈。
