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: 能否在胃肠道中存活,这是个问题!

: To Survive, or Not to Survive the Gastrointestinal Tract, That Is the Question!

机构信息

Department of Food Environmental and Nutritional Sciences (DeFENS), University of Milan, via Celoria 2, 20133 Milan, Italy.

出版信息

Nutrients. 2020 Jul 22;12(8):2175. doi: 10.3390/nu12082175.

Abstract

The probiotic market is increasing world-wide as well as the number of products marketed as probiotics. Among the latter, many products contain strains at several dosages. However, the scientific evidence that should support the probiotic status of those strains is often contradictory. This review analyses the scientific literature aimed to assess the ability of strains to survive the human gastrointestinal tract by discussing the scientific validity of the methods applied for the bacterial recovery and identification from stool samples. This review highlights that in most of the intervention studies reviewed, the identification of strains from stools was not carried out with the necessary taxonomic accuracy to avoid their misidentification with , a common human commensal and a species phylogenetically close to . Moreover, this review highlights how critical the accurate taxonomic identification of in metagenomics-based studies can be.

摘要

益生菌市场在全球范围内不断增长,作为益生菌销售的产品数量也在增加。在后者中,许多产品含有几种剂量的菌株。然而,支持这些菌株益生菌地位的科学证据往往存在矛盾。本综述分析了旨在评估 菌株在人类胃肠道中存活能力的科学文献,通过讨论从粪便样本中回收和鉴定细菌所应用的方法的科学有效性来进行分析。本综述强调,在大多数综述的干预研究中,从粪便中鉴定 菌株时,并没有进行必要的分类学准确性,以避免将其与 错误鉴定, 是一种常见的人类共生菌,与 亲缘关系密切。此外,本综述还强调了在基于宏基因组学的研究中,准确鉴定 菌株的重要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de85/7468695/7741d1a88806/nutrients-12-02175-g001.jpg

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