Gallina Laura, Savini Federica, Canziani Sabrina, Frasnelli Matteo, Lavazza Antonio, Scagliarini Alessandra, Lelli Davide
Dipartimento di Scienze Mediche Veterinarie, Alma Mater Studiorum Università di Bologna, 40064 Ozzano Emilia, Italy.
Istituto Zooprofilattico Sperimentale della Lombardia e dell'Emilia Romagna "Bruno Ubertini" (IZSLER), 25124 Brescia, Italy.
Pathogens. 2020 Jul 17;9(7):583. doi: 10.3390/pathogens9070583.
We describe two cases of skin co-infections with epitheliotropic viruses, detected in two cattle during lumpy skin disease (LSD) surveillance in northern Italy. A diagnostic protocol including different molecular methods as well as negative staining electron microscopy was applied to detect the most common viral agents belonging to the family , and which cause skin diseases in cattle. Two specimens were collected from cases clinically diagnosed as papillomatosis and pseudo-LSD. Both skin lesions were shown to harbor more than one viral species. This case report shows, for the first time, co-infection of zoonotic parapoxvirus with bovine papillomavirus and herpesvirus in skin lesions of cattle. In particular, the simultaneous presence of virions morphologically referable to parapoxvirus and papillomavirus confirms that the replication of both viruses in the same lesion can happen and the so-called papillomatosis can bear zoonotic viruses.
我们描述了两例在意大利北部进行牛结节性皮肤病（LSD）监测期间，在两头牛身上检测到的上皮嗜性病毒皮肤合并感染病例。应用了包括不同分子方法以及负染色电子显微镜在内的诊断方案，以检测属于 、 和 科的最常见病毒病原体，这些病原体可导致牛的皮肤疾病。从临床诊断为乳头瘤病和假性LSD的病例中采集了两份标本。两个皮肤病变均显示含有不止一种病毒。本病例报告首次显示，在牛的皮肤病变中，人畜共患副痘病毒与牛乳头瘤病毒和疱疹病毒合并感染。特别是，形态上可归为副痘病毒和乳头瘤病毒的病毒粒子同时存在，证实了两种病毒可在同一病变中复制，且所谓的乳头瘤病可能携带人畜共患病毒。
