新冠疫情对实体器官捐赠的影响：意大利北部移植项目经验
The Impact of COVID-19 on Solid Organ Donation: The North Italy Transplant Program Experience.
作者信息
Cannavò Antonino, Passamonti Serena Maria, Martinuzzi Daniela, Longobardi Antonio, Fiorattini Andrea, Troni Nicoletta Margherita, Esposito Martha Helena, Dell'orefice Nicolina, Torelli Rosanna, De Feo Tullia Maria
机构信息
Unità Operativa Complessa (UOC) Coordinamento Trapianti, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Ca' Granda-Ospedale Maggiore Policlinico, Milan, Italy.
Unità Operativa Complessa (UOC) Coordinamento Trapianti, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Ca' Granda-Ospedale Maggiore Policlinico, Milan, Italy.
出版信息
Transplant Proc. 2020 Nov;52(9):2578-2583. doi: 10.1016/j.transproceed.2020.06.025. Epub 2020 Jun 25.
BACKGROUND
The coronavirus disease 2019 (COVID-19) outbreak has unfavorably influenced solid organ donation activity.
AIM
The aim of this study is to investigate the effect of COVID-19 on transplantation in the North Italy Transplant program (NITp).
MATERIAL AND METHODS
This cross-sectional study included all consecutive potential deceased donors proposed in the NITp in 6 weeks after February 21, 2020 (period A) compared to all potential donors during the same time frame of the previous years (period B) and all potential donors 6 weeks before February 20, 2020 (period C).
RESULTS
Fifty-eight deceased donors were proposed during period A, 95 were proposed during period B, and 128 were proposed during period C. After the evaluation process, 32 of 58 (55.2%), 60 of 95 (63.2%), and 79 of 128 (61.7%) donors were used for organ donation in periods A, B, and C, respectively (P value = .595). We observed a 47% donation reduction in period A compared to period B and a 60% reduction compared to period C. There was a reduction of 44% and 59% in transplantation comparing period A with period B and period C, respectively.
CONCLUSIONS
This study showed an important reduction of donations and transplants during the COVID-19 pandemic.
背景
2019年冠状病毒病（COVID-19）疫情对实体器官捐赠活动产生了不利影响。
目的
本研究旨在调查COVID-19对意大利北部移植项目（NITp）中移植手术的影响。
材料与方法
这项横断面研究纳入了2020年2月21日之后6周内在NITp中提出的所有连续潜在已故捐赠者（A期），并与前几年同一时间段的所有潜在捐赠者（B期）以及2020年2月20日之前6周的所有潜在捐赠者（C期）进行比较。
结果
A期提出了58名已故捐赠者，B期提出了95名，C期提出了128名。经过评估过程，A期、B期和C期分别有58名中的32名（55.2%）、95名中的60名（63.2%）和128名中的-79名（61.7%）捐赠者用于器官捐赠（P值 = 0.595）。我们观察到，与B期相比，A期捐赠减少了47%，与C期相比减少了60%。与B期和C期相比，A期移植分别减少了44%和59%。
结论
本研究表明，在COVID-19大流行期间，捐赠和移植数量大幅减少。
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