Department of Translational Medical Science, Section of Pediatrics, University of Naples "Federico II", Via S. Pansini, 5, 80131, Naples, Italy.
Clinical Department of Pediatrics and Neonatology, San Paolo Hospital, ASST Santi Paolo e Carlo, University of Milan, Milan, Italy.
Ital J Pediatr. 2020 Jul 25;46(1):104. doi: 10.1186/s13052-020-00862-z.
During the last decade several paediatric studies have been published with different possible indications for probiotics, leading to a global increase of probiotics' market. Nevertheless, different study designs, multiple single/combined strains and small sample size still leave many uncertainties regarding their efficacy. In addition, different regulatory and quality control issues make still very difficult the interpretation of the clinical data. The objective of this review is to critically summarise the current evidence on probiotics' efficacy and safety on a different number of pathologies, including necrotizing enterocolitis, acute infectious diarrhoea, allergic diseases and functional gastrointestinal disorders in order to guide paediatric healthcare professionals on using evidence-based probiotics' strains. To identify relevant data, literature searches were performed including Medline-PubMed, the Cochrane Library and EMBASE databases. Considering probiotics strain-specific effects, the main focus was on individual probiotic strains and not on probiotics in general.
在过去的十年中，已经发表了几项儿科研究，涉及益生菌的不同可能适应症，导致益生菌市场的全球增长。然而，不同的研究设计、多种单一/联合菌株和小样本量仍然存在许多关于其疗效的不确定性。此外，不同的监管和质量控制问题使得对临床数据的解释仍然非常困难。本综述的目的是批判性地总结益生菌在不同疾病中的疗效和安全性的现有证据，包括坏死性小肠结肠炎、急性感染性腹泻、过敏性疾病和功能性胃肠疾病，以便指导儿科医疗保健专业人员使用基于证据的益生菌菌株。为了确定相关数据，进行了文献检索，包括 Medline-PubMed、Cochrane 图书馆和 EMBASE 数据库。考虑到益生菌菌株特异性效应，主要关注的是单个益生菌菌株，而不是一般的益生菌。
