School of Chemical Sciences, The University of Auckland, Symonds Street, Auckland 1010, New Zealand.
School of Chemical Sciences, The University of Auckland, Symonds Street, Auckland 1010, New Zealand and Maurice Wilkins Centre of Molecular Biodiscovery, The University of Auckland, Symonds Street, Auckland 1010, New Zealand.
Nat Prod Rep. 2021 Mar 4;38(2):330-345. doi: 10.1039/d0np00039f.
Covering: up to 2020 ent-Atisane diterpenoids are a class of over 150 members with diverse structures and valuable bioactivities. These compounds share a curious history in which the synthesis of the archetypal member preceded its isolation from natural sources. In this review, we provide a comprehensive summary of the isolation, structure, and bioactivity of ent-atisane diterpenoids from their discovery in 1965 to the present day.
截至 2020 年,ent-Atisane 二萜类化合物是一个拥有超过 150 个成员的多样化结构和具有重要生物活性的化合物家族。这些化合物具有一个奇特的历史,即原型成员的合成先于其从天然来源中的分离。在这篇综述中,我们提供了从 1965 年发现至今,ent-atisane 二萜类化合物的分离、结构和生物活性的全面总结。