金黄色葡萄球菌菌血症患者合并菌尿症的临床意义。
Clinical significance of concomitant bacteriuria in patients with Staphylococcus aureus bacteraemia.
机构信息
Infection Prevention and Control Unit, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
Infectious Diseases Service, Lausanne University Hospital and University of Lausanne, 1011, Lausanne, Switzerland.
出版信息
Eur J Clin Microbiol Infect Dis. 2023 Mar;42(3):379-382. doi: 10.1007/s10096-023-04559-z. Epub 2023 Feb 2.
This retrospective study, conducted at Lausanne University Hospital (2015-2021), compared Staphylococcus aureus bacteraemia (SABA) patients with or without concomitant bacteriuria (SABU). Among 448 included bacteraemic patients, 62 (13.8%) had S. aureus concurrently isolated from urine. In multivariate analysis, there was a significant difference in the odds of community-onset bacteraemia (P 0.030), malignancy (P 0.002), > 1 pair of positive blood cultures (P 0.037), and persistent bacteraemia for at least 48 h (P 0.045) in patients with concurrent SABU. No difference concerning mortality was found. On the other hand, SABU was associated with higher rates of SABA recurrence after antibiotic cessation.
本回顾性研究在洛桑大学医院（2015-2021 年）进行，比较了伴有或不伴有合并菌尿症的金黄色葡萄球菌菌血症（SABA）患者。在 448 例菌血症患者中，62 例（13.8%）从尿液中同时分离出金黄色葡萄球菌。多变量分析显示，社区获得性菌血症（P<0.030）、恶性肿瘤（P<0.002）、>1 对阳性血培养（P<0.037）和至少持续 48 小时的持续性菌血症（P<0.045）的发生几率在合并菌尿症的患者中有显著差异。但在死亡率方面未发现差异。另一方面，SABU 与抗生素停药后金黄色葡萄球菌菌血症复发率较高有关。
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