Institute of Infection and Global Health, University of Liverpool, Liverpool, UK
Institute of Infection and Global Health, University of Liverpool, Liverpool, UK.
Vet Rec. 2020 Oct 31;187(9):357. doi: 10.1136/vr.105890. Epub 2020 Jul 27.
Reports of disease and production losses associated with , the common liver fluke, have increased in recent years. Resistance to triclabendazole, one of the principal veterinary medicines used to prevent losses, has been reported and is now considered widespread in fluke endemic regions of the UK.
Thirteen farmers participated in a trial in 2013 and the triclabendazole resistance status was obtained for each farm. Based on these results, a knowledge exchange programme on fluke control was delivered to nearly 100 farmers in the region. In this follow-up study, 11 farmers involved in the original trial, participated in semistructured in-depth qualitative interviews in July 2017.
Overall, participants identified benefits from participating in the 2013 trial, gaining information about triclabendazole resistance on their farms and knowledge about fluke control. The information on their farm's resistance status was a driver for changing their liver fluke control programmes. Factors such as habitual and repetitive behaviours, grazing restrictions due to agri-environmental schemes, economic pressures and climate change were identified that could impede or prevent the adoption of new control strategies.
The study highlights the significance of resistance to triclabendazole and the impact of knowledge exchange programmes in changing liver fluke control practices.
近年来，与常见肝吸虫病相关的疾病和生产损失报告有所增加。作为预防损失的主要兽医药物之一，三氯苯达唑的耐药性已被报道，并被认为在英国肝吸虫病流行地区广泛存在。
13 位农民参与了 2013 年的一项试验，对每个农场的三氯苯达唑耐药情况进行了评估。根据这些结果，在该地区向近 100 位农民提供了肝吸虫病控制知识交流计划。在这项后续研究中，11 位参与原始试验的农民于 2017 年 7 月参与了半结构化深度定性访谈。
总体而言，参与者认为参与 2013 年试验有好处，他们从试验中获得了关于其农场的三氯苯达唑耐药性信息和肝吸虫病控制知识。其农场耐药性状况的信息是改变其肝吸虫病控制计划的驱动因素。一些因素，如习惯性和重复性行为、由于农业环境计划而受到的放牧限制、经济压力和气候变化，可能会阻碍或阻止新控制策略的采用。
该研究强调了三氯苯达唑耐药性的重要性以及知识交流计划在改变肝吸虫病控制实践方面的作用。
