Skull Base Research Center, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
BMC Psychiatry. 2022 May 23;22(1):351. doi: 10.1186/s12888-022-04007-w.
Angiotensin-converting enzyme (ACE) as an important enzyme in the renin-angiotensin system facilitates biogenesis of the functionally active product angiotensin II from angiotensin I. ACE gene contains a number of functional polymorphisms which modulate activity of the encoded protein. In the current case-control study, we appraised the association between the rs4359 and rs1799752 polymorphisms and risk of bipolar disorder (type I and type II; BPDI and BPDII), schizophrenia (SCZ) and obsessive-compulsive disorder (OCD). The rs4359 was associated with risk of OCD, BPDI and BPDII in co-dominant and dominant models. The rs1799752 was associated with all assessed psychiatric conditions in four inheritance models except for BPDII whose association was not significant in recessive model. The I allele of rs1799752 was associated with OCD (adjusted FDR q-Value = 4.04E-04), SCZ (adjusted FDR q-Value = 6.00E-06), BPDI (adjusted FDR q-Value = 8.40E-03) and BPDII (adjusted FDR q-Value = 6.00E-06). The effective T allele of rs4359 showed a significant association with disease risk for BPDII group. The estimated haplotypes of these polymorphisms have been distributed differently among patients and controls. Taken together, ACE polymorphisms can be regarded as risk factors for a variety of psychiatric disorders.
血管紧张素转换酶（ACE）作为肾素-血管紧张素系统中的一种重要酶，促进血管紧张素 I 生成具有生物学活性的血管紧张素 II。ACE 基因包含多个功能多态性，这些多态性调节编码蛋白的活性。在目前的病例对照研究中，我们评估了 rs4359 和 rs1799752 多态性与双相障碍（I 型和 II 型；BPDI 和 BPDII）、精神分裂症（SCZ）和强迫症（OCD）风险之间的关联。rs4359 在共显性和显性模型中与 OCD、BPDI 和 BPDII 的风险相关。rs1799752 在四种遗传模型中与所有评估的精神疾病相关，除了 BPDII 在隐性模型中的关联不显著。rs1799752 的 I 等位基因与 OCD（调整后的 FDR q 值=4.04E-04）、SCZ（调整后的 FDR q 值=6.00E-06）、BPDI（调整后的 FDR q 值=8.40E-03）和 BPDII（调整后的 FDR q 值=6.00E-06）相关。rs4359 的有效 T 等位基因与 BPDII 组的疾病风险显著相关。这些多态性的估计单倍型在患者和对照组中的分布不同。总之，ACE 多态性可被视为多种精神疾病的风险因素。
