Department of Medicine, Hebrew University-Hadassah Medical Center, Jerusalem, Israel.
Obes Rev. 2021 Feb;22(2):e13108. doi: 10.1111/obr.13108. Epub 2020 Jul 27.
Adropin is a peptide hormone, which plays a role in energy homeostasis and controls glucose and fatty acid metabolism. Its levels correlate with changes in carbohydrate-lipid metabolism, metabolic diseases, central nervous system function, endothelial function and cardiovascular disease. Both metabolic pathways and adropin are regulated by the circadian clocks. Here, we review the roles of the autonomic nervous system and circadian rhythms in regulating metabolic pathways and energy homeostasis. The beneficial effects of chronotherapy in various systems are discussed. We suggest a potential role for adropin as a mediator of the metabolic system-autonomic nervous system axis. We discuss the possibility of establishing an individualized adropin and circadian rhythm-based platform for implementing chronotherapy, and variability signatures for improving the efficacy of adropin-based therapies are discussed.
分泌素是一种肽激素，在能量平衡中发挥作用，并控制葡萄糖和脂肪酸代谢。其水平与碳水化合物-脂质代谢的变化、代谢疾病、中枢神经系统功能、内皮功能和心血管疾病相关。代谢途径和分泌素均受昼夜节律钟的调节。在这里，我们综述了自主神经系统和昼夜节律在调节代谢途径和能量平衡中的作用。讨论了时间治疗在各种系统中的有益效果。我们提出分泌素作为代谢系统-自主神经系统轴的中介的潜在作用。我们讨论了建立基于分泌素和昼夜节律的个体化平台来实施时间治疗的可能性，并讨论了改善基于分泌素治疗效果的可变性特征。
