Department of Neurology, Laboratory of Neurogenetics, University Hospital of Larissa, Greece, Faculty of Medicine, School of Health Sciences, University of Thessaly, Larissa, Greece.
Department of Neurology, Laboratory of Neurogenetics, University Hospital of Larissa, Greece, Faculty of Medicine, School of Health Sciences, University of Thessaly, Larissa, Greece.
Sci Total Environ. 2020 Nov 20;744:140591. doi: 10.1016/j.scitotenv.2020.140591. Epub 2020 Jun 29.
Parkinson's disease (PD) is a common neurodegenerative disorder that leads to significant morbidity and decline in the quality of life. It develops due to loss of dopaminergic neurons in the substantia nigra pars compacta, and among its pathogenic factors oxidative stress plays a critical role in disease progression. Pesticides are a broad class of chemicals widely used in agriculture and households for the protection of crops from insects and fungi. Several of them have been incriminated as risk factors for PD, but the underlying mechanisms have yet to be fully understood. MicroRNAs (miRNAs) are small, non-coding RNA molecules that play an important role in regulating mRNA translation and protein synthesis. miRNA levels have been shown to be affected in several diseases as well. Since the studies on the association between pesticides and PD have yet to reach definitive conclusions, here we review recent evidence on deregulated microRNAs upon pesticide exposure, and attempt to find an overlap between miRNAs deregulated in PD and pesticides, as a missing link between the two, and enhance future research in this direction.
帕金森病（PD）是一种常见的神经退行性疾病，会导致发病率显著上升和生活质量下降。它是由于黑质致密部多巴胺能神经元的丧失引起的，其致病因素中氧化应激在疾病进展中起着关键作用。农药是一类广泛应用于农业和家庭的化学品，用于保护作物免受昆虫和真菌的侵害。其中有几种已被指控为 PD 的危险因素，但潜在的机制尚未完全了解。microRNAs（miRNAs）是一类小的非编码 RNA 分子，在调节 mRNA 翻译和蛋白质合成方面发挥着重要作用。miRNA 水平在几种疾病中也被证明受到影响。由于关于农药和 PD 之间关联的研究尚未得出明确的结论，因此，我们在这里回顾了最近关于农药暴露时 miRNA 失调的证据，并试图在 PD 中失调的 miRNA 和农药之间找到一个重叠，作为两者之间的缺失环节，并加强这一方向的未来研究。
