Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
Department of Pediatrics, St. Michael's Hospital, Toronto, Ontario, Canada.
Public Health Nutr. 2021 Nov;24(16):5436-5442. doi: 10.1017/S1368980020001925. Epub 2020 Jul 29.
To evaluate the association between the age of cow milk introduction and childhood growth.
A secondary analysis of a prospective cohort study.
Toronto, Canada.
Healthy children <5 years of age enrolled in the TARGet Kids! practice-based research network. The primary exposure was the age of cow milk introduction. The primary outcome was height-for-age z-score. Secondary outcomes were volume of cow milk consumed (cups/d) and BMI z-score. Outcomes were measured at the last visit before 5 years of age. Multiple linear regression was used to examine these relationships.
Among 1981 children, introduction of cow milk at a younger age was associated with greater height by 3-5 years of age (P < 0·001). Each month earlier that cow milk was introduced was associated with 0·03 higher height-for-age z-score unit (95 % CI -0·05, -0·02) or 0·1 cm (95 % CI -0·15, -0·12 cm). At 4 years of age, the height difference between a child introduced to cow milk at 9 v. 12 months was 0·4 cm (95 % CI -0·45, -0·35 cm). There was no association between the timing of cow milk introduction and volume of cow milk consumed per day or BMI z-score.
Earlier introduction of cow milk was associated with greater height but not with weight status in children aged 3-5 years. Further research is needed to understand the casual relationship between earlier cow milk consumption and childhood height. These findings may be important for paediatricians and parents when considering when to introduce cow milk.
评估牛奶引入年龄与儿童生长的关系。
一项前瞻性队列研究的二次分析。
加拿大多伦多。
纳入 TARGet Kids!基于实践的研究网络的 5 岁以下健康儿童。主要暴露因素为牛奶引入年龄。主要结局指标为身高年龄 z 评分。次要结局指标为牛奶摄入量(杯/天)和 BMI z 评分。在 5 岁前的最后一次就诊时测量这些结果。采用多元线性回归分析这些关系。
在 1981 名儿童中,牛奶引入年龄越小,3 至 5 岁时身高越高(P<0·001)。牛奶引入时间提前一个月与身高年龄 z 评分增加 0·03 相关(95 % CI -0·05,-0·02)或 0·1 厘米(95 % CI -0·15,-0·12 厘米)。4 岁时,牛奶引入时间为 9 个月与 12 个月的儿童身高差异为 0·4 厘米(95 % CI -0·45,-0·35 厘米)。牛奶引入时间与每日牛奶摄入量或 BMI z 评分之间无关联。
牛奶引入时间较早与 3 至 5 岁儿童身高较高相关,但与体重状况无关。需要进一步研究以了解早期牛奶消费与儿童身高之间的因果关系。这些发现对于儿科医生和家长在考虑何时引入牛奶时可能很重要。