电针通过调节Th17和Treg之间的免疫平衡改善自发性高血压大鼠的血压。
Electroacupuncture Improves Blood Pressure in SHRs by Regulating the Immune Balance between Th17 and Treg.
作者信息
Wang Yang, Zhang Lili, Li Li, Hu Hantong, Pan Pan, Zhang Baoyu, Ning Wenhua, Zhao Mengxiong, Wang Shu
机构信息
First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China.
Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China.
出版信息
Evid Based Complement Alternat Med. 2020 Jul 7;2020:5375981. doi: 10.1155/2020/5375981. eCollection 2020.
The present study investigated the effects of electroacupuncture on blood pressure in spontaneously hypertensive rats (SHRs) by regulating the immune balance of T helper 17 cells (Th17 cells) and regulatory T cells (Treg cells). This study investigated the role of electroacupuncture in the immune balance of SHRs using Western blot, flow cytometry, and ELISA techniques. Electroacupuncture significantly improved blood pressure, downregulated the expression of RORt, and upregulated the expression of Foxp3, reduced the production of Th17 cells, promoted the production of Treg cells, reduced the secretion of IL-6 and IL-17, and increased the secretion of TGF-1 and IL-10. These findings suggest that electroacupuncture therapy effectively improved the systolic blood pressure of SHRs, and its mechanism may be related to promotion of the immune balance between Th17 and Treg.
本研究通过调节辅助性T细胞17（Th17细胞）和调节性T细胞（Treg细胞）的免疫平衡，探讨电针对自发性高血压大鼠（SHRs）血压的影响。本研究采用蛋白质印迹法、流式细胞术和酶联免疫吸附测定技术，研究电针在SHRs免疫平衡中的作用。电针可显著改善血压，下调RORt的表达，上调Foxp3的表达，减少Th17细胞的产生，促进Treg细胞的产生，减少IL-6和IL-17的分泌，并增加TGF-1和IL-10的分泌。这些结果表明，电针疗法可有效改善SHRs的收缩压，其机制可能与促进Th17和Treg之间的免疫平衡有关。
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