Institute of Cardiovascular Disease of Integrated Traditional Chinese and Western Medicine, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Department of Cardiovascular Disease, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Front Immunol. 2023 Feb 23;14:1126761. doi: 10.3389/fimmu.2023.1126761. eCollection 2023.
Cardiovascular diseases (CVDs) are the leading cause of death and disability worldwide. The CVDs are accompanied by inflammatory progression, resulting in innate and adaptive immune responses. Regulatory T cells (Tregs) have an immunosuppressive function and are one of the subsets of CD4T cells that play a crucial role in inflammatory diseases. Whether using Tregs as a biomarker for CVDs or targeting Tregs to exert cardioprotective functions by regulating immune balance, suppressing inflammation, suppressing cardiac and vascular remodeling, mediating immune tolerance, and promoting cardiac regeneration in the treatment of CVDs has become an emerging research focus. However, Tregs have plasticity, and this plastic Tregs lose immunosuppressive function and produce toxic effects on target organs in some diseases. This review aims to provide an overview of Tregs' role and related mechanisms in CVDs, and reports on the research of plasticity Tregs in CVDs, to lay a foundation for further studies targeting Tregs in the prevention and treatment of CVDs.
心血管疾病（CVDs）是全球范围内死亡和残疾的主要原因。CVDs 伴随着炎症进展，导致先天和适应性免疫反应。调节性 T 细胞（Tregs）具有免疫抑制功能，是 CD4T 细胞的亚群之一，在炎症性疾病中发挥着关键作用。无论是将 Tregs 用作 CVDs 的生物标志物，还是通过调节免疫平衡、抑制炎症、抑制心脏和血管重塑、介导免疫耐受以及促进心脏再生来靶向 Tregs 发挥心脏保护功能，在 CVDs 的治疗中已成为新兴的研究焦点。然而，Tregs 具有可塑性，这种可塑性 Tregs 在某些疾病中会失去免疫抑制功能，并对靶器官产生毒性作用。本综述旨在概述 Tregs 在 CVDs 中的作用和相关机制，并报告关于 CVDs 中可塑性 Tregs 的研究，为进一步研究靶向 Tregs 预防和治疗 CVDs 奠定基础。
