Ou Yangguang, Buchanan Anna Marie, Witt Colby E, Hashemi Parastoo
Department of Chemistry and Biochemistry, University of South Carolina, Columbia SC.
Anal Methods. 2019 Jun 6;11(21):2738-2755. doi: 10.1039/c9ay00055k. Epub 2019 May 16.
It is extremely challenging to chemically diagnose disorders of the brain. There is hence great interest in designing and optimizing tools for direct detection of chemical biomarkers implicated in neurological disorders to improve diagnosis and treatment. Tools that are capable of monitoring brain chemicals, neurotransmitters in particular, need to be biocompatible, perform with high spatiotemporal resolution, and ensure high selectivity and sensitivity. Recent advances in electrochemical methods are addressing these criteria; the resulting devices demonstrate great promise for neurotransmitter detection. None of these devices are currently used for diagnostic purposes, however these cutting-edge technologies are promising more sensitive, selective, faster, and less invasive measurements. this review we highlight significant technical advances and studies, performed in the last 5 years, that we believe will facilitate the development of diagnostic tools for brain disorders.
对大脑疾病进行化学诊断极具挑战性。因此，人们对设计和优化用于直接检测与神经疾病相关的化学生物标志物的工具以改善诊断和治疗有着浓厚兴趣。能够监测大脑化学物质，尤其是神经递质的工具，需要具备生物相容性，具有高时空分辨率，并确保高选择性和高灵敏度。电化学方法的最新进展正在满足这些标准；由此产生的设备在神经递质检测方面显示出巨大潜力。然而，目前这些设备都未用于诊断目的，不过这些前沿技术有望实现更灵敏、更具选择性、更快且侵入性更小的测量。在本综述中，我们重点介绍过去5年取得的重大技术进展和开展的研究，我们认为这些将推动大脑疾病诊断工具的开发。
