Department of Neurology, University Hospital of Saarland, Kirrberger Straße, 66421 Homburg, Germany.
Behav Neurol. 2020 Jul 17;2020:4329297. doi: 10.1155/2020/4329297. eCollection 2020.
Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is an effective therapy for Parkinson's disease (PD). Nevertheless, DBS has been associated with certain nonmotor, neuropsychiatric effects such as worsening of emotion recognition from facial expressions. In order to investigate facial emotion recognition (FER) after STN DBS, we conducted a literature search of the electronic databases MEDLINE and Web of science. In this review, we analyze studies assessing FER after STN DBS in PD patients and summarize the current knowledge of the effects of STN DBS on FER. The majority of studies, which had clinical and methodological heterogeneity, showed that FER is worsening after STN DBS in PD patients, particularly for negative emotions (sadness, fear, anger, and tendency for disgust). FER worsening after STN DBS can be attributed to the functional role of the STN in limbic circuits and the interference of STN stimulation with neural networks involved in FER, including the connections of the STN with the limbic part of the basal ganglia and pre- and frontal areas. These outcomes improve our understanding of the role of the STN in the integration of motor, cognitive, and emotional aspects of behaviour in the growing field of affective neuroscience. Further studies using standardized neuropsychological measures of FER assessment and including larger cohorts are needed, in order to draw definite conclusions about the effect of STN DBS on emotional recognition and its impact on patients' quality of life.
深部脑刺激（DBS）丘脑底核（STN）是治疗帕金森病（PD）的有效方法。然而，DBS 与某些非运动性、神经精神效应有关，例如面部表情识别的恶化。为了研究 STN DBS 后的面部情绪识别（FER），我们对 MEDLINE 和 Web of science 电子数据库进行了文献检索。在这篇综述中，我们分析了评估 PD 患者 STN DBS 后 FER 的研究，并总结了目前关于 STN DBS 对 FER 影响的知识。大多数研究具有临床和方法学异质性，表明 PD 患者 STN DBS 后 FER 恶化，尤其是对负性情绪（悲伤、恐惧、愤怒和厌恶倾向）。STN DBS 后 FER 恶化可归因于 STN 在边缘回路中的功能作用以及 STN 刺激对 FER 相关神经网络的干扰，包括 STN 与基底神经节边缘部分以及前和额区的连接。这些结果提高了我们对 STN 在运动、认知和情感行为整合中的作用的理解，这是情感神经科学这一不断发展领域的一部分。需要进一步研究，使用 FER 评估的标准化神经心理学测量方法，并包括更大的队列，以便对 STN DBS 对情绪识别的影响及其对患者生活质量的影响得出明确的结论。
