Int J Oral Maxillofac Implants. 2020 Jul/Aug;35(4):707-720. doi: 10.11607/jomi.8097.
The purpose of this study was to provide sufficient information on the clinical outcome of zirconia implants, mainly observing the survival rate and marginal bone loss (MBL), with a minimum follow-up of 12 months, to verify the adoption of ceramics as a rational possibility for dental implants.
A systematic electronic search through the PubMed (MEDLINE) and EMBASE databases was performed by two independent reviewers to identify clinical studies published between January 2005 and April 2019 containing a minimum of 10 patients per study and 12 months of follow-up after functional loading. References from the selected articles were manually reviewed for further studies.
From the initial 1,225 articles retrieved, 19 met all the inclusion criteria. The marginal bone remodeling accounted for mean losses of 0.8 mm (95% CI: 0.60 to 1.00 mm) and 1.01 mm (95% CI: 0.72 to 1.29 mm) at 1 year and 2 years postloading, respectively. The failure rate of 6.8% was calculated for a mean follow-up period of 2.75 years, where the prevalence of early failure, late failure, and implant fracture was 3.4%, 1.7%, and 1.7%, respectively. The meta-analysis associated with the survival rate of one- and two-piece zirconia dental implants was hindered due to the lack of confidence interval or standard deviation information in most of the included articles.
Zirconia implants presented MBL values consistent with the standard in the global consensus, high survival rates, and considerable clinical results at short-term observation periods following prosthetic delivery.
本研究旨在提供有关氧化锆种植体临床结果的充分信息，主要观察种植体的存活率和边缘骨吸收（MBL），随访时间至少为 12 个月，以验证将陶瓷作为一种合理的种植牙可能性。
通过两名独立的审查员对 PubMed（MEDLINE）和 EMBASE 数据库进行了系统的电子搜索，以确定 2005 年 1 月至 2019 年 4 月期间发表的包含每个研究至少 10 名患者和功能加载后 12 个月随访的临床研究。从选定的文章中手动审查参考文献以获取进一步的研究。
从最初检索到的 1225 篇文章中，有 19 篇符合所有纳入标准。边缘骨重塑在负荷后 1 年和 2 年分别导致平均损失 0.8mm（95%置信区间：0.60 至 1.00mm）和 1.01mm（95%置信区间：0.72 至 1.29mm）。平均随访 2.75 年后，计算出 6.8%的失败率，其中早期失败、晚期失败和种植体骨折的患病率分别为 3.4%、1.7%和 1.7%。由于大多数纳入的文章缺乏置信区间或标准差信息，因此与一体式和分体式氧化锆牙科种植体存活率相关的荟萃分析受到阻碍。
氧化锆种植体在全球共识中具有一致的 MBL 值、高存活率和在短期观察期内相当可观的临床效果。
