Sun Lin-Xi, Xie Yan-Ming, Liu Huan, Li Yuan-Yuan, Zhuang Yan
Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences Beijing 100700, China Xiyuan Hospital, China Academy of Chinese Medical Sciences Beijing 100091, China.
Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences Beijing 100700, China.
Zhongguo Zhong Yao Za Zhi. 2020 Aug;45(15):3505-3510. doi: 10.19540/j.cnki.cjcmm.20200428.501.
To explore the real world clinical application characteristics and the drug combination regularity of Ciwujia Injection, 12 554 cases of patients with Ciwujia Injection were extracted from the information systems of 24 class Ⅲ grade A hospitals in China, and a standardized analysis was carried out. Most of the patients were middle-aged and old-aged, and the main departments were cardiovascular department(22.50%) and neurology department(17.92%). Before 2008, 93.77% of the patients were single overdose users, which reduced to only 2.07% after 2011. The course of treatment was mostly between 8-14 days(32.98%). The top three di-seases diagnosed by Western medicine were hypertension(11.78%), cerebral infarction(9.47%), and coronary heart disease(8.15%), and the most common traditional Chinese medicine syndrome was the deficiency of liver and kidney(18.59%). The most commonly used Western medicine was Acetylsalicylic Acid(51.07%), and the most commonly used traditional Chinese medicine was Danshen Injection(9.67%). The most commonly used Western medicine in combined application was calcium channel blocker(46.88%), and the most commonly used traditional Chinese medicine in combined application was stasis removing agent(93.21%). And the drug combination with the highest support was Isosorbide Mononitrate + Acetylsalicylic Acide, with a high recovery rate after discharge(96.81%). The results showed that Ciwujia Injection had certain regularity. It considered underlying concurrent diseases, anticoagulation and blood circulation, with a wide range of effects in strengthening the body and regulating the mind. The results could expand the understanding of Ciwujia Injection and provide a more detailed real world basis and reference for optimizing therapeutic regimen in clinic.
为探讨刺五加注射液的真实世界临床应用特点及药物联用规律，从我国24家三级甲等医院信息系统中提取12554例使用刺五加注射液的患者资料，并进行规范分析。患者以中老年为主，主要科室为心血管科（22.50%）和神经内科（17.92%）。2008年前，93.77%的患者为单药过量使用，2011年后降至仅2.07%。疗程多在8 - 14天（32.98%）。西医诊断前三位的疾病为高血压（11.78%）、脑梗死（9.47%）、冠心病（8.15%），最常见的中医证型为肝肾亏虚（18.59%）。最常用的西药是阿司匹林（51.07%），最常用的中药是丹参注射液（9.67%）。联用中最常用的西药是钙通道阻滞剂（46.88%），最常用的中药是活血化瘀剂（93.21%）。支持率最高的药物联用是单硝酸异山梨酯 +阿司匹林，出院后恢复率较高（96.81%）。结果表明，刺五加注射液具有一定规律，兼顾基础合并症、抗凝及血液循环，在扶正安神方面作用广泛。研究结果可拓展对刺五加注射液的认识，为临床优化治疗方案提供更详实的真实世界依据和参考。
