Department for Molecular and Medical Virology, Ruhr University Bochum, Bochum, Germany.
European Virus Bioinformatics Center, Jena, Germany.
J Infect Dis. 2020 Sep 14;222(8):1289-1292. doi: 10.1093/infdis/jiaa471.
The ongoing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic creates a significant threat to global health. Recent studies suggested the significance of throat and salivary glands as major sites of virus replication and transmission during early coronavirus disease 2019, thus advocating application of oral antiseptics. However, the antiviral efficacy of oral rinsing solutions against SARS-CoV-2 has not been examined. Here, we evaluated the virucidal activity of different available oral rinses against SARS-CoV-2 under conditions mimicking nasopharyngeal secretions. Several formulations with significant SARS-CoV-2 inactivating properties in vitro support the idea that oral rinsing might reduce the viral load of saliva and could thus lower the transmission of SARS-CoV-2.
持续的严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）大流行对全球健康构成重大威胁。最近的研究表明，在新冠病毒疾病 2019 早期，喉咙和唾液腺是病毒复制和传播的主要部位，因此提倡使用口腔消毒剂。然而，口腔冲洗液对 SARS-CoV-2 的抗病毒功效尚未得到检验。在这里，我们在模拟鼻咽分泌物的条件下，评估了不同口腔冲洗液对 SARS-CoV-2 的病毒杀灭活性。几种具有显著体外 SARS-CoV-2 灭活特性的配方支持这样一种观点，即口腔冲洗可能会降低唾液中的病毒载量，从而降低 SARS-CoV-2 的传播。
