Buoso Erica, Masi Mirco, Long Aideen, Chiappini Camilla, Travelli Cristina, Govoni Stefano, Racchi Marco
Department of Drug Sciences, University of Pavia, Pavia, Italy.
Scuola Universitaria Superiore IUSS Pavia, Pavia, Italy.
Br J Pharmacol. 2022 Jun;179(12):2813-2828. doi: 10.1111/bph.15218. Epub 2020 Aug 26.
Ribosomes coordinate spatiotemporal control of gene expression, contributing to the acquisition and maintenance of cancer phenotype. The link between ribosomes and cancer is found in the roles of individual ribosomal proteins in tumorigenesis and cancer progression, including the ribosomal protein, receptor for activated C kinase 1 (RACK1). RACK1 regulates cancer cell invasion and is localized in spreading initiation centres, structural adhesion complexes containing RNA binding proteins and poly-adenylated mRNAs that suggest a local translation process. As RACK1 is a ribosomal protein directly involved in translation and in breast cancer progression, we propose a new molecular mechanism for breast cancer cell migration and invasion, which considers the molecular differences between epithelial and mesenchymal cell profiles in order to characterize and provide novel targets for therapeutic strategies. Hence, we provide an analysis on how ribosomes translate cancer progression with a final focus on the ribosomal protein RACK1 in breast cancer. LINKED ARTICLES: This article is part of a themed issue on New avenues in cancer prevention and treatment (BJP 75th Anniversary). To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v179.12/issuetoc.
核糖体协调基因表达的时空控制，有助于癌症表型的获得和维持。核糖体与癌症之间的联系在于单个核糖体蛋白在肿瘤发生和癌症进展中的作用，包括核糖体蛋白、活化C激酶1受体（RACK1）。RACK1调节癌细胞侵袭，并定位于铺展起始中心，这是一种包含RNA结合蛋白和多聚腺苷酸化mRNA的结构粘附复合物，提示存在局部翻译过程。由于RACK1是一种直接参与翻译和乳腺癌进展的核糖体蛋白，我们提出了一种乳腺癌细胞迁移和侵袭的新分子机制，该机制考虑了上皮细胞和间充质细胞特征之间的分子差异，以便为治疗策略鉴定和提供新的靶点。因此，我们分析了核糖体如何转化癌症进展，最终聚焦于乳腺癌中的核糖体蛋白RACK1。相关文章：本文是关于癌症预防和治疗新途径（《英国药理学杂志》75周年）主题特刊的一部分。要查看本节中的其他文章，请访问http://onlinelibrary.wiley.com/doi/10.lll/bph.v179.12/issuetoc。
