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酿酒酵母辐射敏感突变体rad10和rad16中胸腺嘧啶二聚体切除缺陷。

Defective thymine dimer excision in radiation-sensitive mutants rad10 and rad16 of Saccharomyces cerevisiae.

作者信息

Prakash L

出版信息

Mol Gen Genet. 1977 Apr 29;152(3):125-8. doi: 10.1007/BF00268808.

DOI:10.1007/BF00268808
PMID:327268
Abstract

Two rad mutants of yeast, rad10 and rad16, are shown to be defective in the removal of UV-induced pyrimidine dimers since DNAs obtained from irradiated cells following a post-irradiation incubation in the dark still retain UV-endonuclease-sensitive sites. Both rad10 and rad16 mutants are in the same pathway of excision-repair as the rad1, rad2, rad3 and rad4 mutants.

摘要

酵母的两个rad突变体rad10和rad16，被证明在去除紫外线诱导的嘧啶二聚体方面存在缺陷，因为在黑暗中进行辐照后培养，从受辐照细胞中获得的DNA仍保留紫外线内切酶敏感位点。rad10和rad16突变体与rad1、rad2、rad3和rad4突变体处于相同的切除修复途径。

相似文献

1
Defective thymine dimer excision in radiation-sensitive mutants rad10 and rad16 of Saccharomyces cerevisiae.酿酒酵母辐射敏感突变体rad10和rad16中胸腺嘧啶二聚体切除缺陷。
Mol Gen Genet. 1977 Apr 29;152(3):125-8. doi: 10.1007/BF00268808.
2
Ultraviolet-endonuclease activity in cell extracts of Saccharomyces cerevisiae mutants defective in excision of pyrimidine dimers.在嘧啶二聚体切除缺陷的酿酒酵母突变体细胞提取物中的紫外线内切核酸酶活性。
J Bacteriol. 1980 Apr;142(1):322-4. doi: 10.1128/jb.142.1.322-324.1980.
3
Molecular mechanisms of pyrimidine dimer excision in Saccharomyces cerevisiae: incision of ultraviolet-irradiated deoxyribonucleic acid in vivo.酿酒酵母中嘧啶二聚体切除的分子机制：体内紫外线照射的脱氧核糖核酸的切割
J Bacteriol. 1981 May;146(2):692-704. doi: 10.1128/jb.146.2.692-704.1981.
4
Incision and postincision steps of pyrimidine dimer removal in excision-defective mutants of Saccharomyces cerevisiae.酿酒酵母切除缺陷型突变体中嘧啶二聚体去除的切割及切割后步骤。
J Bacteriol. 1981 Nov;148(2):618-23. doi: 10.1128/jb.148.2.618-623.1981.
5
Molecular mechanisms of pyrimidine dimer excision in Saccharomyces cerevisiae: excision of dimers in cell extracts.酿酒酵母中嘧啶二聚体切除的分子机制：细胞提取物中二聚体的切除
J Bacteriol. 1981 Aug;147(2):705-8. doi: 10.1128/jb.147.2.705-708.1981.
6
Repair of UV-irradiated plasmid DNA in mutants of Saccharomyces cerevisiae and Escherichia coli deficient in repair of pyrimidine dimers.酿酒酵母和大肠杆菌嘧啶二聚体修复缺陷突变体中紫外线照射质粒DNA的修复
Acta Biochim Pol. 1987;34(4):461-76.
7
Genetic control of excision of Saccharomyces cerevisiae interstrand DNA cross-links induced by psoralen plus near-UV light.补骨脂素加近紫外光诱导的酿酒酵母链间DNA交联切除的遗传控制
Mol Cell Biol. 1982 Aug;2(8):939-48. doi: 10.1128/mcb.2.8.939-948.1982.
8
Repair of pyrimidine dimers in radiation-sensitive mutants rad3, rad4, rad6 and rad9 of Saccharomyces cerevisiae.酿酒酵母辐射敏感突变体rad3、rad4、rad6和rad9中嘧啶二聚体的修复
Mutat Res. 1977 Oct;45(1):13-20. doi: 10.1016/0027-5107(77)90038-0.
9
Repair of 6-4 photoproducts and cyclobutane pyrimidine dimers in rad mutants of Saccharomyces cerevisiae.酿酒酵母rad突变体中6-4光产物和环丁烷嘧啶二聚体的修复
Mutat Res. 1994 Nov;315(3):261-73. doi: 10.1016/0921-8777(94)90037-x.
10
Molecular cloning of the RAD10 gene of Saccharomyces cerevisiae.酿酒酵母RAD10基因的分子克隆
Gene. 1985;34(1):55-61. doi: 10.1016/0378-1119(85)90294-x.

引用本文的文献

1
Interactions among genes controlling sensitivity to radiation (RAD) and to alkylation by nitrogen mustard (SNM) in yeast.酵母中控制辐射敏感性（RAD）和氮芥烷化作用（SNM）的基因之间的相互作用。
Curr Genet. 1982 May;5(1):33-8. doi: 10.1007/BF00445738.
2
Genomewide screen for negative regulators of sirtuin activity in Saccharomyces cerevisiae reveals 40 loci and links to metabolism.对酿酒酵母中沉默调节蛋白活性负调控因子进行全基因组筛选，发现40个基因座并与代谢建立联系。
Genetics. 2008 Aug;179(4):1933-44. doi: 10.1534/genetics.108.088443. Epub 2008 Aug 9.
3
Isolation and characterization of the RAD3 gene of Saccharomyces cerevisiae and inviability of rad3 deletion mutants.

本文引用的文献

1
Effect of Genes Controlling Radiation Sensitivity on Chemically Induced Mutations in SACCHAROMYCES CEREVISIAE.控制辐射敏感性的基因对酿酒酵母中化学诱导突变的影响。
Genetics. 1976 Jun;83(2):285-301. doi: 10.1093/genetics/83.2.285.
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Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
J Biol Chem. 1951 Nov;193(1):265-75.
3
Cytoplasmic and nuclear genetic events induced by UV light in strains of Saccharomyces cerevisiae with different UV sensitivities.紫外线在不同紫外线敏感性的酿酒酵母菌株中诱导的细胞质和细胞核遗传事件。
酵母细胞 RAD3 基因的分离与鉴定及其缺失突变体的致死性。
Proc Natl Acad Sci U S A. 1983 Sep;80(18):5680-4. doi: 10.1073/pnas.80.18.5680.
4
Evidence that the Rad1 and Rad10 proteins of Saccharomyces cerevisiae participate as a complex in nucleotide excision repair of UV radiation damage.酿酒酵母的Rad1和Rad10蛋白作为一个复合体参与紫外线辐射损伤的核苷酸切除修复的证据。
J Bacteriol. 1993 Oct;175(19):6345-7. doi: 10.1128/jb.175.19.6345-6347.1993.
5
Incision and postincision steps of pyrimidine dimer removal in excision-defective mutants of Saccharomyces cerevisiae.酿酒酵母切除缺陷型突变体中嘧啶二聚体去除的切割及切割后步骤。
J Bacteriol. 1981 Nov;148(2):618-23. doi: 10.1128/jb.148.2.618-623.1981.
6
Molecular mechanisms of pyrimidine dimer excision in Saccharomyces cerevisiae: excision of dimers in cell extracts.酿酒酵母中嘧啶二聚体切除的分子机制：细胞提取物中二聚体的切除
J Bacteriol. 1981 Aug;147(2):705-8. doi: 10.1128/jb.147.2.705-708.1981.
7
Molecular mechanisms of pyrimidine dimer excision in Saccharomyces cerevisiae: incision of ultraviolet-irradiated deoxyribonucleic acid in vivo.酿酒酵母中嘧啶二聚体切除的分子机制：体内紫外线照射的脱氧核糖核酸的切割
J Bacteriol. 1981 May;146(2):692-704. doi: 10.1128/jb.146.2.692-704.1981.
8
Relation between liquid-holding recovery, DNA repair, and mitotic recombination in the rad3 mutant of Saccharomyces cerevisiae after treatment with diepoxybutane (DEB).用1,4 - 丁二醇二缩水甘油醚（DEB）处理后，酿酒酵母rad3突变体中持液恢复、DNA修复与有丝分裂重组之间的关系。
Mol Gen Genet. 1980;180(3):597-603. doi: 10.1007/BF00268066.
9
A new mutant of the yeast Saccharomyces cerevisiae defective in excision of UV-damaged sites in DNA.一种酿酒酵母的新突变体，其在切除DNA中紫外线损伤位点方面存在缺陷。
Mol Gen Genet. 1980 Feb;177(3):541-4. doi: 10.1007/BF00271495.
10
Defective excision of pyrimidine dimers and interstrand DNA crosslinks in rad7 and rad23 mutants of Saccharomyces cerevisiae.酿酒酵母rad7和rad23突变体中嘧啶二聚体和链间DNA交联的切除缺陷。
Mol Gen Genet. 1982;188(2):235-9. doi: 10.1007/BF00332681.
Mutat Res. 1969 Mar-Apr;7(2):171-85. doi: 10.1016/0027-5107(69)90029-3.
4
The isolation, genetics and survival characteristics of ultraviolet light-sensitive mutants in yeast.酵母中紫外线敏感突变体的分离、遗传学及存活特性
Mutat Res. 1968 Jul-Aug;6(1):37-55. doi: 10.1016/0027-5107(68)90101-2.
5
Four radiation sensitive mutants of Saccharomyces. Survival after UV- and x-ray-irradiation as well as UV-induced reversion rates from isoleucine-valine dependence to independence.酿酒酵母的四个辐射敏感突变体。紫外线和X射线照射后的存活率以及紫外线诱导的从异亮氨酸 - 缬氨酸依赖型到非依赖型的回复突变率。
Mol Gen Genet. 1970;107(2):117-27. doi: 10.1007/BF00333628.
6
[The effects of mutations towards ultraviolet sensitivity in yeast].[酵母中对紫外线敏感性突变的影响]
Mutat Res. 1970 Jan;9(1):31-9. doi: 10.1016/0027-5107(70)90068-0.
7
Genetic control of radiation sensitivity in Saccharomyces cerevisiae.酿酒酵母辐射敏感性的遗传控制
Genetics. 1969 Jul;62(3):519-31. doi: 10.1093/genetics/62.3.519.
8
The effects of UV-light post-treatments on the survival characteristics of 21 UV-sensitive mutants of Saccharomyces cerevisiae.紫外线后处理对21株酿酒酵母紫外线敏感突变体存活特性的影响。
Mutat Res. 1969 Nov-Dec;8(3):545-57. doi: 10.1016/0027-5107(69)90072-4.
9
Kinetics and genetic control of the incorporation of thymidine monophosphate in yeast DNA.酵母DNA中一磷酸胸苷掺入的动力学及遗传控制
Mol Gen Genet. 1972;117(1):39-44. doi: 10.1007/BF00268835.
10
The excision of pyrimidine dimers from DNA of ultraviolet irradiated yeast.从紫外线照射的酵母DNA中切除嘧啶二聚体。
Mol Gen Genet. 1971;113(4):359-62. doi: 10.1007/BF00272336.