酿酒酵母辐射敏感突变体rad10和rad16中胸腺嘧啶二聚体切除缺陷。
Defective thymine dimer excision in radiation-sensitive mutants rad10 and rad16 of Saccharomyces cerevisiae.
作者信息
Prakash L
出版信息
Mol Gen Genet. 1977 Apr 29;152(3):125-8. doi: 10.1007/BF00268808.
PMID:327268
Abstract
Two rad mutants of yeast, rad10 and rad16, are shown to be defective in the removal of UV-induced pyrimidine dimers since DNAs obtained from irradiated cells following a post-irradiation incubation in the dark still retain UV-endonuclease-sensitive sites. Both rad10 and rad16 mutants are in the same pathway of excision-repair as the rad1, rad2, rad3 and rad4 mutants.
摘要
酵母的两个rad突变体rad10和rad16，被证明在去除紫外线诱导的嘧啶二聚体方面存在缺陷，因为在黑暗中进行辐照后培养，从受辐照细胞中获得的DNA仍保留紫外线内切酶敏感位点。rad10和rad16突变体与rad1、rad2、rad3和rad4突变体处于相同的切除修复途径。
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