前哨淋巴结阳性乳腺癌患者非前哨淋巴结转移的预测因素。
Predictive Factors for Non-sentinel Nodal Metastasis in Patients With Sentinel Lymph Node-positive Breast Cancer.
机构信息
Department of Breast Oncology, Juntendo University School of Medicine, Tokyo, Japan.
Department of Breast Oncology, Juntendo University School of Medicine, Tokyo, Japan
出版信息
Anticancer Res. 2020 Aug;40(8):4405-4412. doi: 10.21873/anticanres.14445.
BACKGROUND
Axillary dissection is routinely conducted for all patients with sentinel node (SN)-positive breast cancer. Metastasis to non SNs is not often found after axillary dissection in patients with SN-positive breast cancer. Thus, we investigated clinicopathological features, including immune cells in peripheral blood, in order to identify factors related to metastasis to non-SNs.
PATIENTS AND METHODS
We retrospectively investigated 184 patients with SN-positive disease, treated at our institution during the 2013 through 2018 period. All clinicopathological data were obtained before and during surgery.
RESULTS
Metastasis to non SNs was observed in 64 cases (35%). The platelet-to-lymphocyte ratio (PLR) and the number of SN metastases were independent of metastasis to non SNs (p=0.023 and p=0.017, respectively). Patients with metastasis to non SNs had significantly lower PLR and more SN metastases. High lymphocyte number and low platelet number resulted in a low PLR.
CONCLUSION
PLR might be a marker of metastasis to non SNs.
背景
腋窝清扫术通常用于所有前哨淋巴结（SN）阳性乳腺癌患者。在 SN 阳性乳腺癌患者中，腋窝清扫术后通常不会在非 SN 中发现转移。因此，我们研究了包括外周血免疫细胞在内的临床病理特征，以确定与非 SN 转移相关的因素。
患者和方法
我们回顾性调查了 184 例在 2013 年至 2018 年期间在我院治疗的 SN 阳性疾病患者。所有临床病理数据均在术前和手术期间获得。
结果
64 例（35%）观察到非 SN 转移。血小板与淋巴细胞比值（PLR）和 SN 转移数量与非 SN 转移无关（p=0.023 和 p=0.017）。发生非 SN 转移的患者 PLR 明显较低，SN 转移数量较多。高淋巴细胞数和低血小板数导致低 PLR。
结论
PLR 可能是非 SN 转移的标志物。
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