癌细胞如何补充燃料供应？
How do cancer cells replenish their fuel supply?
机构信息
Division of Cardiac Surgery, Baystate Medical Center, Springfield, MA, USA.
Anesthesiology, Baystate Medical Center, Springfield, MA, USA.
出版信息
Cancer Rep (Hoboken). 2018 Jun;1(1):e1003. doi: 10.1002/cnr2.1003. Epub 2018 Apr 30.
BACKGROUND
Multiple genetic changes, availability of cellular nutrients and metabolic alterations play a pivotal role in oncogenesis AIMS: We focus on cancer cell's metabolic properties, and we outline the cross talks between cellular oncogenic growth pathways in cancer metabolism. The review also provides a synopsis of the relevant cancer drugs targeting metabolic activities that are at various stages of clinical development.
METHODS
We review literature published within the last decade to include select articles that have highlighted energy metabolism crucial to the development of cancer phenotypes.
RESULTS
Cancer cells maintain their potent metabolism and keep a balanced redox status by enhancing glycolysis and autophagy and rerouting Krebs cycle intermediates and products of β-oxydation.
CONCLUSIONS
The processes underlying cancer pathogenesis are extremely complex and remain elusive. The new field of systems biology provides a mathematical framework in which these homeostatic dysregulation principles may be examined for better understanding of cancer phenotypes. Knowledge of key players in cancer-related metabolic reprograming may pave the way for new therapeutic metabolism-targeted drugs and ultimately improve patient care.
背景
多种遗传改变、细胞营养物质的可用性和代谢改变在肿瘤发生中起着关键作用。
目的
我们关注癌细胞的代谢特性，并概述致癌生长途径在癌症代谢中的相互作用。本综述还概述了针对不同临床开发阶段的代谢活性的相关癌症药物。
方法
我们回顾了过去十年发表的文献，包括强调对癌症表型发展至关重要的能量代谢的精选文章。
结果
癌细胞通过增强糖酵解和自噬以及重路由克雷布斯循环中间体和β-氧化产物来维持其强大的代谢并保持平衡的氧化还原状态。
结论
癌症发病机制背后的过程极其复杂，仍然难以捉摸。系统生物学的新领域为检查这些体内平衡失调原则提供了一个数学框架，以便更好地了解癌症表型。对与癌症相关的代谢重编程中的关键参与者的了解可能为新的治疗代谢靶向药物铺平道路，并最终改善患者护理。
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