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重金属与皮肤:立陶宛金属工人的致敏模式。

Heavy metals and the skin: Sensitization patterns in Lithuanian metalworkers.

机构信息

Vilnius University, Faculty of Medicine, Institute of Clinical Medicine, Clinic of Chest diseases, Immunology and Allergology, Vilnius, Lithuania.

Lund University, Skåne University Hospital, Department of Occupational and Environmental Dermatology, Malmö, Sweden.

出版信息

Contact Dermatitis. 2020 Dec;83(6):450-457. doi: 10.1111/cod.13681. Epub 2020 Aug 26.

DOI:10.1111/cod.13681
PMID:32729629
Abstract

BACKGROUND

Metalworkers are exposed to many sensitizing and irritant substances. There are no published data on contact allergy in this population in the Baltic countries.

OBJECTIVES

To detect skin symptoms related to occupational exposure and to describe the reactivity pattern to the European baseline series in workers from two metal plants in Lithuania.

METHODS

In this cross-sectional study 185 metalworkers (154 production workers and 31 office staff) filled an interviewer-administered questionnaire. Patch testing was performed in 135 metalworkers and office staff, as a control group.

RESULTS

Metalworkers younger than 40 years complained statistically significantly more often of skin symptoms, especially on the hands and face, than older workers. Physician-diagnosed skin diseases were reported in 1.7% of cases. Metalworkers, working <20 years in the factory, more often had skin symptoms. Contact with chemicals at the workplace was suspected as the main factor provoking skin symptoms. Metalworkers were sensitized mainly to cobalt, and nickel was the most prevalent allergen among office staff.

CONCLUSION

Younger metalworkers more often had skin symptoms suspected of being work-related compared to older ones. Sensitization to cobalt was more prevalent in the metalworkers than in the control group.

摘要

背景

金属工人暴露于许多致敏和刺激物质中。波罗的海国家尚无该人群接触过敏的发表数据。

目的

检测与职业暴露相关的皮肤症状,并描述立陶宛两家金属厂工人对欧洲基本系列的反应模式。

方法

在这项横断面研究中,185 名金属工人(154 名生产工人和 31 名办公室工作人员)填写了一份由调查员管理的问卷。对 135 名金属工人和办公室工作人员进行了斑贴试验,作为对照组。

结果

年龄小于 40 岁的金属工人比年龄较大的工人更频繁地报告手部和面部皮肤症状,统计学上有显著差异。有 1.7%的病例报告了医生诊断的皮肤病。在工厂工作不到 20 年的金属工人更常出现皮肤症状。接触工作场所的化学品被怀疑是引发皮肤症状的主要因素。金属工人主要对钴过敏,而镍是办公室工作人员中最常见的过敏原。

结论

与年长的金属工人相比,年轻的金属工人更常出现疑似与工作相关的皮肤症状。金属工人对钴的致敏率高于对照组。

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Heavy metals and the skin: Sensitization patterns in Lithuanian metalworkers.重金属与皮肤:立陶宛金属工人的致敏模式。
Contact Dermatitis. 2020 Dec;83(6):450-457. doi: 10.1111/cod.13681. Epub 2020 Aug 26.
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Contact sensitization in metalworkers: Data from the information network of departments of dermatology (IVDK), 2010-2018.金属工人中的接触致敏:来自皮肤科部门信息网络(IVDK)的 2010-2018 年数据。
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Occupational exposure to nickel, cobalt, and chromium in the Lithuanian hard metal industry.立陶宛硬金属行业中镍、钴和铬的职业接触。
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Int Arch Occup Environ Health. 2004 Nov;77(8):543-51. doi: 10.1007/s00420-004-0539-9. Epub 2004 Nov 9.
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