Information Network of Departments of Dermatology (IVDK), Institute at the University Medical Center Göttingen, Göttingen, Germany.
Lower Saxony Institute of Occupational Dermatology, University Medical Center Göttingen, Göttingen, Germany.
Contact Dermatitis. 2020 Dec;83(6):487-496. doi: 10.1111/cod.13686. Epub 2020 Oct 7.
Metalworkers are exposed to a variety of contact allergens by handling tools, metals, metalworking fluids (MWFs), oils and greases, rubber materials, and so on. Most large-scale reports on contact allergy due to MWFs are more than 10-years-old, and there are only few studies on contact allergy in mechanics and other metal workers not exposed to MWFs.
To describe a current spectrum of contact sensitization in metalworkers with occupational dermatitis (OD).
Retrospective analysis of patch test data collected by the Information Network of Departments of Dermatology (IVDK; 2010-2018), stratifying for 804 cutting metalworkers, 2197 mechanics, and 355 other metalworkers.
Cutting metalworkers were most frequently sensitized to monoethanolamine (12.6%), colophonium/abietic acid (11.4%) and formaldehyde releasers (up to 8.5%) from the MWF series, and formaldehyde (4.6%) and iodopropynyl butylcarbamate (4.6%) from the baseline series. Sensitization among mechanics and other metalworkers indicates possible occupational exposure to MWFs, glues, and resins, although this may not be expected from their job titles.
The spectrum of MWF contact allergens remained largely unchanged during the last years. Taking a comprehensive occupational history is indispensable in order to not miss relevant allergen exposures.
金属工人在处理工具、金属、金属加工液(MWF)、油和油脂、橡胶材料等时会接触到各种接触性过敏原。大多数关于 MWF 引起接触过敏的大规模报告都已有 10 多年的历史,而关于未接触 MWF 的机械师和其他金属工人接触过敏的研究则很少。
描述职业性皮炎(OD)金属工人中当前接触致敏的情况。
对皮肤科信息网络(IVDK;2010-2018 年)收集的斑贴试验数据进行回顾性分析,分层为 804 名切割金属工人、2197 名机械师和 355 名其他金属工人。
切割金属工人最常对 MWF 系列中的单乙醇胺(12.6%)、松香/松香酸(11.4%)和甲醛释放剂(高达 8.5%),以及基础系列中的甲醛(4.6%)和碘丙炔基丁基氨基甲酸酯(4.6%)敏感。机械师和其他金属工人的敏感表明他们可能接触过 MWF、胶水和树脂,尽管这可能与他们的工作头衔不符。
在过去几年中,MWF 接触过敏原的范围基本保持不变。为了不错过相关的过敏原暴露,全面的职业史是必不可少的。