Gcn5 和 Pcaf 在发育和疾病中的复杂功能。
Complex functions of Gcn5 and Pcaf in development and disease.
机构信息
Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Science Park, Smithville, TX 78957, United States of America; Center for Cancer Epigenetics, University of Texas MD Anderson Cancer Center, Houston, TX 77030, United States of America.
Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Science Park, Smithville, TX 78957, United States of America; Center for Cancer Epigenetics, University of Texas MD Anderson Cancer Center, Houston, TX 77030, United States of America.
出版信息
Biochim Biophys Acta Gene Regul Mech. 2021 Feb;1864(2):194609. doi: 10.1016/j.bbagrm.2020.194609. Epub 2020 Jul 28.
A wealth of biochemical and cellular data, accumulated over several years by multiple groups, has provided a great degree of insight into the molecular mechanisms of actions of GCN5 and PCAF in gene activation. Studies of these lysine acetyltransferases (KATs) in vitro, in cultured cells, have revealed general mechanisms for their recruitment by sequence-specific binding factors and their molecular functions as transcriptional co-activators. Genetic studies indicate that GCN5 and PCAF are involved in multiple developmental processes in vertebrates, yet our understanding of their molecular functions in these contexts remains somewhat rudimentary. Understanding the functions of GCN5/PCAF in developmental processes provides clues to the roles of these KATs in disease states. Here we will review what is currently known about the developmental roles of GCN5 and PCAF, as well as emerging role of these KATs in oncogenesis.
多年来，多个研究小组积累了大量的生化和细胞数据，深入了解了 GCN5 和 PCAF 在基因激活中的分子作用机制。这些组蛋白乙酰转移酶 (KAT) 的体外研究和培养细胞研究揭示了它们被序列特异性结合因子招募的一般机制及其作为转录共激活因子的分子功能。遗传研究表明，GCN5 和 PCAF 参与脊椎动物的多种发育过程，但我们对它们在这些情况下的分子功能的理解仍有些初步。了解 GCN5/PCAF 在发育过程中的功能为这些 KAT 在疾病状态中的作用提供了线索。在这里，我们将回顾目前已知的 GCN5 和 PCAF 在发育中的作用，以及这些 KAT 在肿瘤发生中的新兴作用。
Zotero 插件