Na Lei, Bai Yu, Sun Yu, Wang Zhuo, Wang Wei, Yuan Lin, Zhao Chenghai
Department of Pathophysiology, College of Basic Medical Science, China Medical University, Shenyang, China.
Department of Urology, Shengjing Hospital of China Medical University, Shenyang, China.
Front Oncol. 2020 Jul 8;10:1142. doi: 10.3389/fonc.2020.01142. eCollection 2020.
Immune microenvironment within tumors affects initiation, progression and clinical outcome of human cancers. Here we explored an immune-related gene signature associated with prognosis of patients with bladder urothelial carcinoma. The Cancer Genome Atlas (TCGA) database was interrogated for expressions of immune-related genes in bladder urothelial carcinomas. Integrated bioinformatics analyses were performed to identify prognostic factors. Twenty-seven immune-related genes were revealed significantly associated with patient's overall survival (OS) by univariate Cox proportional hazards regression analysis. Nine-core immune-related genes including , and were selected to construct a risk score model by multivariate Cox proportional hazards regression analysis. Bioinformatics analyses further validated that risk score could be used as an important independent factor in evaluating prognosis. We established a prognostic immune signature for patients with bladder urothelial carcinoma, which may provide novel targets for prediction and therapy of these patients.
肿瘤内的免疫微环境影响人类癌症的发生、发展及临床结局。在此，我们探索了一种与膀胱尿路上皮癌患者预后相关的免疫相关基因特征。我们查询了癌症基因组图谱（TCGA）数据库中膀胱尿路上皮癌免疫相关基因的表达情况。进行综合生物信息学分析以确定预后因素。单因素Cox比例风险回归分析显示，27个免疫相关基因与患者的总生存期（OS）显著相关。通过多因素Cox比例风险回归分析，选择了包括 、 和 在内的9个核心免疫相关基因构建风险评分模型。生物信息学分析进一步验证了风险评分可作为评估预后的重要独立因素。我们建立了膀胱尿路上皮癌患者的预后免疫特征，这可能为这些患者的预测和治疗提供新的靶点。
