Massachusetts College of Pharmacy and Health Sciences University, Boston 02115, USA.
Massachusetts College of Pharmacy and Health Sciences University, Boston 02115, USA.
Int J Pharm. 2020 Sep 25;587:119702. doi: 10.1016/j.ijpharm.2020.119702. Epub 2020 Jul 28.
Drug counterfeiting detection is very important for the safety of patients around the world. Counterfeit pharmaceutical products can be referred to the production and distribution of mislabeled medications in which the identity, authenticity, and/or effectiveness is altered. Drugs are often counterfeited to reduce manufacture costs, while still marketing it at as an authentic product. Increased incidence of drug counterfeiting is most noticeable in developing countries, which may not have the resources to supply counterfeit detection devices at a large scale. It is important to consider the direct problems that it may cause and to propose options for controlling and reducing the prevalence of counterfeit medications. Certain counterfeit detection devices have been successfully used for qualitative and quantitative assessment to differentiate counterfeit medications from the reference product. Different technologies are needed to identify the chemical properties of a questioned drug product, which can then be used to determine its authenticity. This review examines the implications of counterfeit medications and the current technological approaches that are able to detect counterfeited pharmaceuticals.
药品造假检测对于全球患者的安全至关重要。假药是指生产和分销的标签有误的药物，其身份、真实性和/或有效性已被篡改。造假者通常会降低药品的制造成本，同时仍将其作为正品进行营销。假药的出现频率在发展中国家最为明显，因为这些国家可能没有资源大规模供应假药检测设备。重要的是要考虑它可能造成的直接问题，并提出控制和减少假药流行的选择。某些假药检测设备已成功用于定性和定量评估，以区分假药和参考产品。需要不同的技术来识别可疑药物产品的化学性质，然后可以使用这些技术来确定其真实性。本文综述了假药的影响以及目前能够检测假药的技术方法。
