School of Public Health, Xinjiang Medical University, Urumqi, Xinjiang, China (mainland).
Department of Joint Surgery, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, China (mainland).
Med Sci Monit. 2020 Aug 1;26:e924202. doi: 10.12659/MSM.924202.
BACKGROUND This study investigated the effect of occupational stress and circadian clock gene polymorphism on sleep disorder of oil workers in Xinjiang, China. MATERIAL AND METHODS We enrolled 2300 Xinjiang oil workers who had been working for at least 1 year. The Chinese revised version of the Occupational Stress Questionnaire (OSI-R), the Pittsburgh Sleep Quality Index (PSQI), and General Survey Questionnaire were used. A total of 308 subjects were selected for stress hormone measurements and gene polymorphism analysis of the circadian clock genes CLOCK, PER2, and PER3. RESULTS The occupational stress scores were influenced by sex, smoking, marital status, age, and work type. Different work shift groups and different professional title groups had statistically significant sleep disorder incidences (P<0.05). The middle and high occupational stress groups had significantly higher subjective sleep quality, total PSQI scores, daytime dysfunction factor scores, and sleep disorder than in the low occupational stress group (P<0.05). CLOCK gene rs1801260 locus carrying TC genotype (OR=0.412, 95% CI=0.245-0.695), and CLOCK gene rs6850524 locus carrying GC and CC genotypes decreased sleep disorder risk (OR₁=0.357, 95% CI₁=0.245-0.695; OR₂=0.317, 95% CI₂=0.128-0.785). The main factors affecting the sleep quality of oil workers were length of service, individual strain capacity, glucocorticoid levels, Per3 gene, and the rs6850524 loci of CLOCK gene. CONCLUSIONS Occupational stress has an adverse effect on the sleep quality of workers. CLOCK gene and Per3 gene may increase risk of sleep disorders.
本研究旨在探讨职业应激和生物钟基因多态性对中国新疆石油工人睡眠障碍的影响。
我们招募了 2300 名在新疆工作至少 1 年的石油工人。采用中文版职业应激问卷（OSI-R）、匹兹堡睡眠质量指数（PSQI）和一般调查问卷进行调查。共选择了 308 名研究对象进行应激激素测量和生物钟基因 CLOCK、PER2 和 PER3 的基因多态性分析。
职业应激评分受到性别、吸烟、婚姻状况、年龄和工作类型的影响。不同轮班组和不同职称组的睡眠障碍发生率存在统计学差异（P<0.05）。中、高职业应激组的主观睡眠质量、总 PSQI 评分、日间功能障碍因子评分和睡眠障碍发生率均显著高于低职业应激组（P<0.05）。CLOCK 基因 rs1801260 位点携带 TC 基因型（OR=0.412，95%CI=0.245-0.695）和 CLOCK 基因 rs6850524 位点携带 GC 和 CC 基因型降低了睡眠障碍风险（OR₁=0.357，95%CI₁=0.245-0.695；OR₂=0.317，95%CI₂=0.128-0.785）。影响石油工人睡眠质量的主要因素有工龄、个体应变能力、糖皮质激素水平、Per3 基因和 CLOCK 基因 rs6850524 位点。
职业应激对工人的睡眠质量有不良影响。CLOCK 基因和 Per3 基因可能会增加睡眠障碍的风险。
